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Professor Massimo CaputoMD(Naples), MCh(Bristol)

Professor of Congenital Heart Surgery

Massimo Caputo

Professor Massimo CaputoMD(Naples), MCh(Bristol)

Professor of Congenital Heart Surgery

Member of

Research interests

Research Interests:

Experimental

  • Transcriptomics and proteonomics in congenital heart disease
  • Identifying the optimal stem cell populations for vascular tissue regeneration used in congenital heart surgery
  • Regenerative stem cell biology for children with heart failure
  • Pulmonary hypertension
  • Bicuspid aortic valve and Marfan syndrome
  • Effect of oxidative stress in cardiomyocytes during different stages of postnatal development
  • The role of mitochondria in increased vulnerability to cardiac insults of hearts and cardiomyocytes isolated from mice fed Western style high-fat diet
  • The role of ventricular arrhythmias in sudden death associated with coronary artery disease
  • Effect of oxidative stress and the role of mitochondria in hearts with chronic coronary artery disease
  • The role of amino acids in cardioprotection
  • Lung protection in cardiopulmonary bypass and cardioplegic arrest

Clinical

  • Improving myocardial protection strategies in paediatric cardiac surgery
  • RCTs on different temperature and oxygen strategies during CPB in children undergoing cardiac surgery (Thermic and Oxic Trials)
  • Imaging and outcomes in adult congenital heart disease
  • Atrial arrhytmias in adult and congenital cardiac diseases
  • Age-related changes in excitation-contraction coupling in paediatric cardiomyocytes
  • Cardioprotection with propofol during adult open heart surgery

Current group members

  • Mohamed Ghorbel, Hua Lin, Sarah Martin, Jihad Hawi, Ben Littlejohns, Simon Duggan

Collaborators

  • UK
    Gianni Angelini, Paolo Madeddu, Andrew Halestrap, Elinor Griffiths, Raimondo Ascione, Jamie Jeremy, Barney Reeves, Andy James, Clive Orchard, Jules Hancox, Mervyn Miles, Claire Stewart.
  • Overseas
    Andrea Venturini (Italy), Hajime Imura (Japan), Nicola King (Australia), Malcolm Underwood (Hong Kong), Chris Howarth (UAE), Camille Nassar (Lebanon).

View research connections

Level 7

Bristol Royal Infirmary

Upper Maudlin Street

Bristol

BS2 8HW

United Kingdom