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Professor Patrick Gavin KehoeBSc(Dub), PhD(Wales)

Gestetner Professor of Translational Dementia Research

Patrick Kehoe

Professor Patrick Gavin KehoeBSc(Dub), PhD(Wales)

Gestetner Professor of Translational Dementia Research

Member of

Research interests

Together with Professor Seth Love, I jointly head the Dementia Research Group, a part of the Institute of Clinical Neurosciences, and the School of Clinical Sciences

My main research interest for over a decade has investigated mechanisms that may underlie the widely acknowledged, but still poorly understood, association between hypertension and blood pressure regulation with respect to the development of Alzheimer’s disease (AD) and other dementias. Of particular interest is the role of the renin angiotensin system (RAS) in the pathology of AD. This increasingly appears to be multifunctional in its associations with many of the pathological pathways recognised in AD including cerebral blood flow reductions, inflammation, neurotransmitter imbalances and oxidative stress. We are currently leading on a multi-site clinical trial (RADAR) of a RAS-acting drug losartan in Alzheimer’s disease. This is based on earlier work we have undertaken on the RAS has also served as a template for other investigations into the behaviour and involvement in AD and other dementias of other related vasomodulatory enzymes such neprilysin, insulin-degrading enzyme and endothelin-converting enzymes.

My other areas of interest include the aetiology of various forms of Vascular Cognitive Impairment (VCI). We undertake research to try and identify genetic risk factors for VCI, potential synergies with genetic risk factors for stroke, but also to undertake research to harmonise the conceptualisation and classification of different forms of VCI.

The Dementia Research Group has a multidisciplinary and applied approach to the investigation of the neuropathology of Alzheimer's disease. This includes the use of genomic and various proteomic/metabolomic approaches further supported by additional molecular biological, cell culture in conjunction with histological and immunohistochemical approaches that are largely underpinned by tissue from the South West Dementia Brain Bank (SWDBB) or Brains for Dementia Research.

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Postal address:
Clinical Neurosciences
University of Bristol
Level 1 Learning and Research Building
Southmead Hospital
Westbury-on-Trym, Bristol
United Kingdom