Skip to content

Full system bifurcation analysis of endocrine bursting models

Research output: Working paperWorking paper and Preprints

  • Thorsten Rieß
  • Arthur Sherman
  • KT Tsaneva-Atanasova
  • HM Osinga
Original languageEnglish
Publication dateSep 2009
StatePublished

Abstract

Plateau bursting is typical of many electrically excitable cells, such as endocrine cells that secrete hormones and some types of neurons that secrete neurotransmitters. Although in many of these cell types the bursting patterns are regulated by the interplay between voltage-gated calcium channels and calcium-sensitive potassium channels, they can be very different. For example, in insulin-secreting pancreatic β-cells, plateau bursting is characterized by well-defined spikes during the depolarized phase whereas in pituitary cells, bursting features fast, irregular, small amplitude spikes. The latter has been termed “pseudo-plateau bursting” because the spikes are transients around a depolarized steady state rather than stable oscillations in the fast subsystem. In this study we systematically investigate the bursting patterns found in endocrine cell models. We show that this class of voltage and calcium gated conductance based models can be reduced to the polynomial model of Hindmarsh and Rose (25). This reduction preserves the main properties of the biophysical class of models that we consider and allows for detailed bifurcation analysis of the full fast-slow system. Our analysis does not require decomposition of the full system into fast and slow subsystems and reveals properties of endocrine bursting that are not captured by the standard fast-slow analysis.

Documents

  • Preprint

    Preprint (usually an early version) , 3 MB, PDF-document

Research areas

  • bifurcation theory, spike adding, excitable systems, endocrine cells, bursting oscillations

View research connections

Related faculties, schools or groups

  1. Full system bifurcation analysis of endocrine bursting models

    Research output: Contribution to journalArticle