|Place of Publication||Decision Support Unit, ScHARR, University of Sheffield|
|Publisher or commissioning body||NICE Decision Support Unit|
|Number of pages||81|
|State||Published - 7 Dec 2016|
|Name||Technical Support Documents|
|Publisher||NICE Decision Support Unit|
This Technical Support Document examines methods for population-adjusted indirect comparisons, in which individual patient data (IPD) in one or more trials are used to adjust for between-trial differences in the distribution of variables that influence outcome. Recently proposed methods are the Matching-Adjusted Indirect Comparison (MAIC) and the Simulated Treatment Comparison (STC). We look at the theory behind MAIC and STC methods, review published applications, briefly touch on alternative methods, and make recommendations on the use of population-adjusted estimates in submissions to NICE.