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NICE DSU Technical Support Document 18: Methods for population-adjusted indirect comparisons in submissions to NICE

Research output: Book/ReportCommissioned report

Original languageEnglish
Place of PublicationDecision Support Unit, ScHARR, University of Sheffield
Publisher or commissioning bodyNICE Decision Support Unit
Number of pages81
Volume18
StatePublished - 7 Dec 2016

Publication series

NameTechnical Support Documents
PublisherNICE Decision Support Unit

Abstract

This Technical Support Document examines methods for population-adjusted indirect comparisons, in which individual patient data (IPD) in one or more trials are used to adjust for between-trial differences in the distribution of variables that influence outcome. Recently proposed methods are the Matching-Adjusted Indirect Comparison (MAIC) and the Simulated Treatment Comparison (STC). We look at the theory behind MAIC and STC methods, review published applications, briefly touch on alternative methods, and make recommendations on the use of population-adjusted estimates in submissions to NICE.

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  • Full-text PDF (final published version) - Technical Support Document 18

    Rights statement: This is the final published version of the article (version of record). It first appeared online via NICE at http://www.nicedsu.org.uk/Populationadjusted-ICs-TSD(3026862).htm. Please refer to any applicable terms of use of the publisher.

    Final published version, 1 MB, PDF-document

  • Supplementary information PDF - Appendix D - Worked example of MAIC and STC

    Rights statement: This is the final published version of the article (version of record). It first appeared online via NICE at http://www.nicedsu.org.uk/Populationadjusted-ICs-TSD(3026862).htm. Please refer to any applicable terms of use of the publisher.

    Final published version, 294 KB, PDF-document

  • Supplementary information PDF - TSD 18 Appendix D - R code

    Rights statement: This is the final published version of the article (version of record). It first appeared online via NICE at http://www.nicedsu.org.uk/Populationadjusted-ICs-TSD(3026862).htm. Please refer to any applicable terms of use of the publisher.

    Final published version, 8 KB, application/octet-stream

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