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Recognition memory-induced gene expression in the perirhinal cortex: A transcriptomic analysis

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalBehavioural Brain Research
Volume328
Early online date4 Apr 2017
DOIs
StatePublished - 15 Jun 2017

Abstract

Abstract We have used transcriptome analysis to identify genes and pathways that are activated during recognition memory formation in the perirhinal cortex. Rats were exposed to objects either repeatedly, so that the objects become familiar, or to novel objects in a bow-tie maze over six consecutive days. On the final day, one hour after the last exposure to the series of objects, RNA from the perirhinal cortex was sequenced to compare the transcriptome of naïve control rats and rats exposed to either novel or familiar stimuli. Differentially expressed genes were identified between group Novel and group Familiar rats. These included genes coding for transcription factors, GDNF receptors and extracellular matrix-related proteins. Moreover, differences in alternative splicing were also detected between the two groups, which suggests that this post-transcriptional mechanism may play a role in the consolidation of object recognition memory. To conclude, this study shows that RNA sequencing can be used as a tool to identify differences in gene expression in behaving animals undergoing the same task but encountering different exposures.

    Research areas

  • Memory, Perirhinal cortex, RNA sequencing, Transcription factor, Alternative splicing, Extracellular matrix

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Elsevier at https://doi.org/10.1016/j.bbr.2017.04.007 . Please refer to any applicable terms of use of the publisher.

    Final published version, 1 MB, PDF-document

    License: CC BY

  • Supplementary information PDF

    Rights statement: This is the final published version of the article (version of record). It first appeared online via Elsevier at https://doi.org/10.1016/j.bbr.2017.04.007 . Please refer to any applicable terms of use of the publisher.

    Final published version, 724 KB, PDF-document

    License: CC BY

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