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Reductive coupling of acrylates with ketones and ketimines via a nickel-catalyzed transfer hydrogenative reductant relay strategy

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Original languageEnglish
JournalAngewandte Chemie International Edition
DOIs
StateAccepted/In press - 22 Aug 2017

Abstract

Ni-catalyzed coupling of benzyl acrylates with activated ketones or imines provides γ-butyrolactones and lactams. The benzyl alcohol byproduct released during the lactonization/lactamization event is relayed to the next cycle where it serves as the reductant for C-C bond formation. This strategy represents a conceptually unique approach to transfer hydrogenative C-C bond formation, providing examples of reductive heterocyclizations where hydrogen embedded within an alcohol leaving group facilitates turnover.

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