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Spatially controlling neuronal adhesion and inflammatory reactions on implantable diamond

Research output: Contribution to journalArticle

Original languageEnglish
Pages557 - 565
Number of pages9
JournalIEEE Journal on Emerging and Selected Topics in Circuits and Systems
Journal publication dateDec 2011
Journal issue4
Volume1
DOIs
StatePublished

Abstract

The mechanical and chemical properties of diamond and diamond-like carbon (DLC) coatings make them very suitable materials for improving the long-term performance of invasive electrode systems used in brain–computer interfaces (BCIs). We have performed in vitro testing to demonstrate methods for spatially directing neural cell growth and limiting the detrimental attachment of cells involved in the foreign body response on boron-doped diamond and DLC. Inkjet-printing, laser micro-machining, and stencil-assisted patterning techniques were used to control neuronal adhesion and modify inflammatory cell attachment. This work presents micro-tailored materials that could be used to improve the long-term quality of recorded signals from neural-electronic interfaces.

Additional information

Publisher: IEEE Rose publication type: Article Sponsorship: This work was supported by Micron Foundation Terms of use: Copyright © 2011 IEEE. Reprinted with permission, from EM Regan, A Taylor, P May, J Uney, A Dick, JP McGeehan; 'Spatially controlling neuronal adhesion and inflammatory reactions on implantable diamond'; IEEE Journal on Emerging and Selected Topics in Circuits and Systems, December 2011. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of the University of Bristol's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.

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Research areas

  • neuron, brain-computer interface, diamond, glia

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