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Dr Jim SpencerB.A.(Cantab.), Ph.D.(Bristol)

Reader in Microbiology

1 - 10 out of 60Page size: 10
  1. 2019
  2. Accepted/In press

    Profiling Interactions of Vaborbactam with Metallo-<beta>-Lactamases

    Langley, G., Cain, R., Tyrrell, J. M., Hinchliffe, P., Calvopina Tapia, K., Tooke, C., Widlake, E., Dowson, C., Spencer, J., Walsh, T., Schofield, C. J. & Brem, J., 16 May 2019, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

    Research output: Contribution to journalArticle

  3. Published

    Exploitation of antibiotic resistance as a novel drug target: development of a β-lactamase-activated antibacterial prodrug

    Evans, L. E., Krishna, A., Ma, Y., Webb, T. E., Marshall, D. C., Tooke, C. L., Spencer, J., Clarke, T. B., Armstrong, A. & Edwards, A. M., 9 May 2019, In : Journal of Medicinal Chemistry. 62, 9, p. 4411-4425 15 p.

    Research output: Contribution to journalArticle

  4. Published

    Simulations of Shikimate Dehydrogenase from Mycobacterium tuberculosis in Complex with 3-Dehydroshikimate and NADPH Suggest Strategies for MtbSDH Inhibition

    Punkvang, A., Kamsri, P., Mulholland, A., Spencer, J., Hannongbua, S. & Pungpo, P., 22 Apr 2019, In : Journal of Chemical Information and Modeling. 59, 4, p. 1422-1433 12 p.

    Research output: Contribution to journalArticle

  5. E-pub ahead of print

    β-Lactamases and β-Lactamase Inhibitors in the 21st Century

    Tooke, C., Hinchliffe, P., Bragginton, E., Colenso, C. K., Hirvonen, V., Takebayashi, Y. & Spencer, J., 5 Apr 2019, In : Journal of Molecular Biology. 29 p.

    Research output: Contribution to journalReview article

  6. Published

    Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants

    Lohans, C. T., Chan, H. T. H., Malla, T. R., Kumar, K., Kamps, J. J. A. G., McArdle, D. J. B., van Groesen, E., de Munnik, M., Tooke, C. L., Spencer, J., Paton, R. S., Brem, J. & Schofield, C. J., 11 Feb 2019, In : Angewandte Chemie - International Edition. 58, 7, p. 1990-1994 5 p.

    Research output: Contribution to journalArticle

  7. Published

    Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases

    Salimraj, R., Hinchliffe, P., Kosmopoulou, M., Tyrrell, J. M., Brem, J., van Berkel, S. S., Verma, A., Owens, R. J., McDonough, M. A., Walsh, T. R., Schofield, C. J. & Spencer, J., Jan 2019, In : FEBS Journal. 286, 1, p. 169-183 15 p.

    Research output: Contribution to journalArticle

  8. 2018
  9. E-pub ahead of print

    Multiscale simulations of clavulanate inhibition identify the reactive complex in class A β-lactamases and predict efficiency of inhibition

    Fritz, R., Alzate-Morales, J. H., Spencer, J., Mulholland, A. J. & Van Der Kamp, M. W., 29 May 2018, In : Biochemistry. 4 p.

    Research output: Contribution to journalArticle

  10. Published

    Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates

    Hinchliffe, P., Tanner, C. A., Krismanich, A. P., Labbé, G., Goodfellow, V. J., Marrone, L., Desoky, A. Y., Calvopiña, K., Whittle, E. E., Zeng, F., Avison, M. B., Bols, N. C., Siemann, S., Spencer, J. & Dmitrienko, G. I., 27 Mar 2018, In : Biochemistry. 57, 12, p. 1880-1892 13 p.

    Research output: Contribution to journalArticle

  11. Published

    Detecting RNA base methylations in single cells by in situ hybridization

    Ranasinghe, R. T., Challand, M. R., Ganzinger, K. A., Lewis, B. W., Softley, C., Schmied, W. H., Horrocks, M. H., Shivji, N., Chin, J. W., Spencer, J. & Klenerman, D., 13 Mar 2018, In : Nature Communications. 9, 1, 10 p., 655.

    Research output: Contribution to journalArticle

  12. Published

    In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors

    Cain, R., Brem, J., Zollman, D., McDonough, M. A., Johnson, R. M., Spencer, J., Makena, A., Abboud, M. I., Cahill, S., Lee, S. Y., McHugh, P. J., Schofield, C. J. & Fishwick, C. W. G., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1255-1260 6 p.

    Research output: Contribution to journalArticle

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