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Dr Jim SpencerB.A.(Cantab.), Ph.D.(Bristol)

Reader in Microbiology

1 - 10 out of 55Page size: 10
  1. 2019
  2. Published

    Crystal structures of VIM‐1 complexes explain active site heterogeneity in VIM‐class metallo‐β‐lactamases

    Spencer, J., Salimraj, R., Hinchliffe, P. & Kosmopoulou, M., Jan 2019, In : FEBS Journal. 286, 1, p. 169-183 15 p.

    Research output: Contribution to journalArticle

  3. 2018
  4. E-pub ahead of print

    Multiscale simulations of clavulanate inhibition identify the reactive complex in class A β-lactamases and predict efficiency of inhibition

    Fritz, R., Alzate-Morales, J. H., Spencer, J., Mulholland, A. J. & Van Der Kamp, M. W., 29 May 2018, In : Biochemistry. 4 p.

    Research output: Contribution to journalArticle

  5. Published

    Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates

    Hinchliffe, P., Tanner, C. A., Krismanich, A. P., Labbé, G., Goodfellow, V. J., Marrone, L., Desoky, A. Y., Calvopiña, K., Whittle, E. E., Zeng, F., Avison, M. B., Bols, N. C., Siemann, S., Spencer, J. & Dmitrienko, G. I., 27 Mar 2018, In : Biochemistry. 57, 12, p. 1880-1892 13 p.

    Research output: Contribution to journalArticle

  6. Published

    Detecting RNA base methylations in single cells by in situ hybridization

    Ranasinghe, R. T., Challand, M. R., Ganzinger, K. A., Lewis, B. W., Softley, C., Schmied, W. H., Horrocks, M. H., Shivji, N., Chin, J. W., Spencer, J. & Klenerman, D., 13 Mar 2018, In : Nature Communications. 9, 1, 10 p., 655.

    Research output: Contribution to journalArticle

  7. Published

    In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors

    Cain, R., Brem, J., Zollman, D., McDonough, M. A., Johnson, R. M., Spencer, J., Makena, A., Abboud, M. I., Cahill, S., Lee, S. Y., McHugh, P. J., Schofield, C. J. & Fishwick, C. W. G., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1255-1260 6 p.

    Research output: Contribution to journalArticle

  8. Published

    A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation

    Lohans, C. T., van Groesen, E., Kumar, K., Tooke, C. L., Spencer, J., Paton, R. S., Brem, J. & Schofield, C. J., Jan 2018, In : Angewandte Chemie - International Edition. 57, 5, p. 1282-1285 4 p.

    Research output: Contribution to journalArticle

  9. 2017
  10. E-pub ahead of print

    Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis

    Abboud, M. I., Kosmopoulou, M., Krismanich, A. P., Johnson, J. W., Hinchliffe, P., Brem, J., Claridge, T. D. W., Spencer, J., Schofield, C. J. & Dmitrienko, G. I., 17 Dec 2017, In : Chemistry - A European Journal. 5 p.

    Research output: Contribution to journalArticle

  11. Published

    Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms

    Yang, Q., Li, M., Spiller, O. B., Andrey, D. O., Hinchliffe, P., Li, H., MacLean, C., Niumsup, P., Powell, L., Pritchard, M., Papkou, A., Shen, Y., Portal, E., Sands, K., Spencer, J., Tansawai, U., Thomas, D., Wang, S., Wang, Y., Shen, J. & Walsh, T., Dec 2017, In : Nature Communications. 8, 12 p., 2054.

    Research output: Contribution to journalArticle

  12. Published

    Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates

    Calvopina Tapia, K., Hinchliffe, P., Brem, J., Heesom, K. J., Johnson, S., Cain, R., Lohans, C. T., Fishwick, C. W. G., Schofield, C. J., Spencer, J. & Avison, M. B., 23 Oct 2017, In : Molecular Microbiology. 106, 3, p. 492–504 13 p.

    Research output: Contribution to journalArticle

  13. Published

    A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

    Lisa, M. N., Palacios, A. R., Aitha, M., González, M. M., Moreno, DI. M., Crowder, M. W., Bonomo, R. A., Spencer, J., Tierney, D. L., Llarrull, L. I. & Vila, A. J., 14 Sep 2017, In : Nature Communications. 8, 538.

    Research output: Contribution to journalArticle

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