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Professor Patricia E KuwabaraB.A.(Johns Hopkins), Ph.D.(Penn.)

William P. Coldrick Chair in Genomics

Patricia Kuwabara

Professor Patricia E KuwabaraB.A.(Johns Hopkins), Ph.D.(Penn.)

William P. Coldrick Chair in Genomics

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Research interests

My lab began using the nematode C. elegans as a multicellular animal model to understand the signalling pathway underlying cell fate decisions controlling sex determination. It was found that a signal transduction pathway, which shares homology with the Hedgehog/Patched (Hh/Ptc) signalling pathway, underlies sexual cell fate decisions. These studies have directly led to our present research interests: 1) The role of calpain proteases in cell signalling and degenerative processes and 2) the role of PTC and PTC-related proteins in cell proliferation and cytokinesis, and osmolarity regulation. We are also taking advantage of the local strengths at the University of Bristol in biochemical structural analysis by forging collaborations that take advantage of the genetic and cell biological tractability of C. elegans to explore the relationships between the structure and function of protein transporters and their effects on cell physiology

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Postal address:
Biomedical Sciences Building
University Walk
Clifton
Bristol
United Kingdom