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Analysing Pathways using ASP-Based approaches

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Original languageEnglish
Title of host publicationAlgebraic and Numeric Biology
Publisher or commissioning bodySpringer
Pages167-183
Number of pages17
ISBN (Print)9783642280665
DOIs
DatePublished - 1 Oct 2011

Abstract

This paper contributes to a line of research which aims to combine numerical information with logical inference in order to find the most likely states of a biological system under various (actual or hypothetical) constraints. To this end, we build upon a state-of-the-art approach that employs weighted Boolean constraints to represent and reason about biochemical reaction networks. Our first contribution is to show how this existing method fails to deal satisfactorily with networks that contain cycles. Our second contribution is to define a new method which correctly handles such cases by exploiting the formalism of Answer Set Programming (ASP). We demonstrate the significance of our results on two case-studies previously studied in the literature

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