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Cellular structures controlling T cell signaling in time and space

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology
Editorsralph bradshaw, Philip Stahl
Place of PublicationWaltham, MA
Publisher or commissioning bodyAcademic Press
Pages677-686
Volume3
ISBN (Print)9780123944474
DOIs
DatePublished - 26 Oct 2015

Abstract

T cell signaling is characterized by the diverse enrichment of receptors and signaling intermediates at particular subcellular regions of the T cell at specific times, resulting in complex spatiotemporal signaling distributions. These signaling distributions control the flow of information through the T cell signaling network and thus govern the efficiency of cellular activation. Here we discuss principal cellular structures driving the organization of T cell signaling including membrane topology, vesicular trafficking, cytoskeletal structures and protein complexes.

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