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Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer

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Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer. / De Poli, Matteo; Zawodny, Wojciech ; Quinonero, Ophélie; Lorch, Mark; Webb, Simon J.; Clayden, Jonathan.

In: Science, Vol. 352, No. 6285, 29.04.2016, p. 575-580.

Research output: Contribution to journalArticle

Harvard

De Poli, M, Zawodny, W, Quinonero, O, Lorch, M, Webb, SJ & Clayden, J 2016, 'Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer', Science, vol. 352, no. 6285, pp. 575-580. https://doi.org/10.1126/science.aad8352

APA

De Poli, M., Zawodny, W., Quinonero, O., Lorch, M., Webb, S. J., & Clayden, J. (2016). Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer. Science, 352(6285), 575-580. https://doi.org/10.1126/science.aad8352

Vancouver

Author

De Poli, Matteo ; Zawodny, Wojciech ; Quinonero, Ophélie ; Lorch, Mark ; Webb, Simon J. ; Clayden, Jonathan. / Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer. In: Science. 2016 ; Vol. 352, No. 6285. pp. 575-580.

Bibtex

@article{e5277be96dce478a96131567f518e957,
title = "Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer",
abstract = "The dynamic properties of foldamers, synthetic molecules that mimic folded biomolecules, have mainly been explored in free solution. Here we report on the design, synthesis, and conformational behavior of photoresponsive foldamers bound in a phospholipid bilayer akin to a biological membrane phase. These molecules contain a chromophore, which can be switched between two configurations by different wavelengths of light, attached to a helical oligoamide that both promotes membrane insertion and communicates conformational change along its length. Light-induced structural changes in the chromophore are translated into global conformational changes, detected by monitoring the solid state 19F nuclear magnetic resonance signals of a remote fluorine-containing residue located 1 to 2 nm away. The behavior of the foldamers in the membrane phase is similar to that of analogous compounds in organic solvents.",
author = "{De Poli}, Matteo and Wojciech Zawodny and Oph{\'e}lie Quinonero and Mark Lorch and Webb, {Simon J.} and Jonathan Clayden",
year = "2016",
month = "4",
day = "29",
doi = "10.1126/science.aad8352",
language = "English",
volume = "352",
pages = "575--580",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6285",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer

AU - De Poli, Matteo

AU - Zawodny, Wojciech

AU - Quinonero, Ophélie

AU - Lorch, Mark

AU - Webb, Simon J.

AU - Clayden, Jonathan

PY - 2016/4/29

Y1 - 2016/4/29

N2 - The dynamic properties of foldamers, synthetic molecules that mimic folded biomolecules, have mainly been explored in free solution. Here we report on the design, synthesis, and conformational behavior of photoresponsive foldamers bound in a phospholipid bilayer akin to a biological membrane phase. These molecules contain a chromophore, which can be switched between two configurations by different wavelengths of light, attached to a helical oligoamide that both promotes membrane insertion and communicates conformational change along its length. Light-induced structural changes in the chromophore are translated into global conformational changes, detected by monitoring the solid state 19F nuclear magnetic resonance signals of a remote fluorine-containing residue located 1 to 2 nm away. The behavior of the foldamers in the membrane phase is similar to that of analogous compounds in organic solvents.

AB - The dynamic properties of foldamers, synthetic molecules that mimic folded biomolecules, have mainly been explored in free solution. Here we report on the design, synthesis, and conformational behavior of photoresponsive foldamers bound in a phospholipid bilayer akin to a biological membrane phase. These molecules contain a chromophore, which can be switched between two configurations by different wavelengths of light, attached to a helical oligoamide that both promotes membrane insertion and communicates conformational change along its length. Light-induced structural changes in the chromophore are translated into global conformational changes, detected by monitoring the solid state 19F nuclear magnetic resonance signals of a remote fluorine-containing residue located 1 to 2 nm away. The behavior of the foldamers in the membrane phase is similar to that of analogous compounds in organic solvents.

UR - http://www.scopus.com/inward/record.url?scp=84962384890&partnerID=8YFLogxK

U2 - 10.1126/science.aad8352

DO - 10.1126/science.aad8352

M3 - Article

VL - 352

SP - 575

EP - 580

JO - Science

JF - Science

SN - 0036-8075

IS - 6285

ER -