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Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

Research output: Contribution to journalArticle

  • Nicholas A Feasey
  • James Hadfield
  • Karen H. Keddy
  • Timothy J Dallman
  • Jan Jacobs
  • Xiangyu Deng
  • Paul Wigley
  • Lars Barquist Barquist
  • Gemma C Langridge
  • Theresa Feltwell
  • Alison E Mather
  • Maria Fookes
  • Martin Aslett
  • Chisomo Msefula
  • Samuel Kariuki
  • Calman A Maclennan
  • Robert S Onsare
  • François-Xavier Weill
  • Simon Le Hello
  • Michael McClelland
  • Prerak Desai
  • Christopher M Parry
  • John Cheesbrough
  • Neil French
  • Josefina Campos
  • Jose A Chabalgoity
  • Laura Betancor
  • Katie L Hopkins
  • Satheesh Nair
  • Octavie Lunguya
  • Tristan A Cogan
  • Milagritos D Tapia
  • Samba O Sow
  • Sharon M Tennant
  • Kristin Bornstein
  • Myron M Levine
  • Dean B Everett
  • Robert A Kingsley
  • Julian Parkhill
  • Gordon Dougan
  • Melita A Gordon
  • Nicholas R Thomson
Original languageEnglish
Pages (from-to)1211-1217
Number of pages7
JournalNature Genetics
Volume48
Issue number10
Early online date22 Aug 2016
DOIs
DateAccepted/In press - 15 Jul 2016
DateE-pub ahead of print - 22 Aug 2016
DatePublished (current) - Oct 2016

Abstract

An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

    Research areas

  • Bacterial infection, Genomics, Microbial genetics

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  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Nature at http://www.nature.com/ng/journal/v48/n10/full/ng.3644.html. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 751 KB, PDF document

  • Supplementary File PPTX - Figures

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Nature at http://www.nature.com/ng/journal/v48/n10/full/ng.3644.html. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 1 MB, application/octet-stream

  • Supplementary Information XLS - Tables

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Nature at http://www.nature.com/ng/journal/v48/n10/full/ng.3644.html. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 85 KB, application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

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