Skip to content

Efficacy and dermal tolerance of a novel alcohol-based skin antiseptic in horses

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)572-577
Number of pages6
JournalVeterinary Surgery
Volume47
Issue number4
Early online date14 Apr 2018
DOIs
DateAccepted/In press - 3 Nov 2017
DateE-pub ahead of print - 14 Apr 2018
DatePublished (current) - May 2018

Abstract

OBJECTIVE: To determine the efficacy and dermal tolerance of a novel alcohol-based skin antiseptic (ABSA) in horses.

STUDY DESIGN: Experimental study.

ANIMAL POPULATION: Systemically healthy horses (n = 25) with no history or clinical signs of skin disease.

METHODS: Four clipped sites on the abdomen were randomly assigned to a skin preparation protocol: saline (negative control; NC), chlorhexidine gluconate followed by isopropyl alcohol (positive control; PC), saline followed by the ABSA (ABSA A), or a commercially available horse shampoo followed by the ABSA (ABSA B). Microbiological swabs were obtained from each site and cultured on MacConkey and mannitol salt agar plates. Colony-forming units were counted 18-24 hours later. All sites were scored for signs of skin reaction before, immediately after, 1 hour after, and 24 hours after skin preparation.

RESULTS: The PC, ABSA A, and ABSA B methods reduced skin microbial burden compared with the NC method (P < .001), but no difference was detected between antiseptic products. Preparation time did not differ between ABSA A and ABSA B methods (P = 0.108); both were faster than the PC method (P < 0.001 for both). Skin reactions were most abundant 24 hours after skin preparation (30.5%), but there was no significant association with antiseptic used, and no horses required veterinary treatment.

CONCLUSION: The ABSA preparations tested in this study were as effective and well tolerated as a chlorhexidine gluconate-based method, but required less time in healthy horses.

CLINICAL SIGNIFICANCE: The ABSA tested here provides an efficacious, fast-acting, and well-tolerated alternative to achieve skin antisepsis in healthy horses. These results justify further investigation in clinical cases.

Download statistics

No data available

Documents

Documents

  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/abs/10.1111/vsu.12793 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 135 KB, PDF document

DOI

View research connections

Related faculties, schools or groups