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Evaluating the carotid bodies and renal nerves as therapeutic targets for hypertension

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)126-130
Number of pages5
JournalAutonomic Neuroscience: Basic and Clinical
Volume204
Early online date3 Aug 2016
DOIs
DateAccepted/In press - 1 Aug 2016
DateE-pub ahead of print - 3 Aug 2016
DatePublished (current) - 1 May 2017

Abstract

Despite the plethora of current treatment options, hypertension remains a difficult condition to adequately control, and there is a pressing need for novel therapeutic strategies. The carotid body has recently become the focus of considerable interest as a potential novel treatment target in essential hypertension. Herein, we appraise the current literature suggesting that the carotid body plays an important causative role to generate sympathetic overactivity and drive increases in arterial pressure, in animal models of hypertension. We also review evidence from human studies showing cardiovascular benefits to the transient inactivation, or surgical removal of carotid bodies, and evaluate the potential benefits of pre-screening to identify patients likely to respond to carotid body-targeted therapy. Finally, given that a high proportion of patients who have undergone renal nerve ablation procedures remain hypertensive, we examine whether the renal nerves are necessary for the drop in blood pressure seen with carotid body removal.

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5 August 2016

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  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at DOI:10.1016/j.autneu.2016.08.002. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 223 KB, PDF document

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