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Exciting Times: New Advances Towards Understanding the Regulation and Roles of Kainate Receptors

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Exciting Times : New Advances Towards Understanding the Regulation and Roles of Kainate Receptors. / Evans, Ash; Gurung, Sonam; Henley, Jeremy; Nakamura, Yasuko; Wilkinson, Kevin.

In: Neurochemical Research, Vol. 44, No. 3, 01.03.2019, p. 572-584.

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Evans, Ash ; Gurung, Sonam ; Henley, Jeremy ; Nakamura, Yasuko ; Wilkinson, Kevin. / Exciting Times : New Advances Towards Understanding the Regulation and Roles of Kainate Receptors. In: Neurochemical Research. 2019 ; Vol. 44, No. 3. pp. 572-584.

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@article{15efa16cc2e8453d8878d4c190627b2f,
title = "Exciting Times: New Advances Towards Understanding the Regulation and Roles of Kainate Receptors",
abstract = "Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in regulating neuronal excitability and network function in the brain. After being cloned in the 1990s, important progress has been made in understanding the mechanisms controlling the molecular and cellular properties of KARs, and the nature and extent of their regulation of wider neuronal activity. However, there have been significant recent advances towards understanding KAR trafficking through the secretory pathway, their precise synaptic positioning, and their roles in synaptic plasticity and disease. Here we provide an overview highlighting these new findings about the mechanisms controlling KARs and how KARs, in turn, regulate other proteins and pathways to influence synaptic function.",
keywords = "Kainate receptors, GluK2, Trafficking, RUSH, Synaptic transmission, Synaptic plasticity, Humans, Protein Transport/physiology, Receptors, Kainic Acid/metabolism, Animals, Membrane Proteins/metabolism, Neurons/metabolism, Neuronal Plasticity/physiology, Brain/metabolism",
author = "Ash Evans and Sonam Gurung and Jeremy Henley and Yasuko Nakamura and Kevin Wilkinson",
year = "2019",
month = "3",
day = "1",
doi = "10.1007/s11064-017-2450-2",
language = "English",
volume = "44",
pages = "572--584",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer US",
number = "3",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Exciting Times

T2 - Neurochemical Research

AU - Evans, Ash

AU - Gurung, Sonam

AU - Henley, Jeremy

AU - Nakamura, Yasuko

AU - Wilkinson, Kevin

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in regulating neuronal excitability and network function in the brain. After being cloned in the 1990s, important progress has been made in understanding the mechanisms controlling the molecular and cellular properties of KARs, and the nature and extent of their regulation of wider neuronal activity. However, there have been significant recent advances towards understanding KAR trafficking through the secretory pathway, their precise synaptic positioning, and their roles in synaptic plasticity and disease. Here we provide an overview highlighting these new findings about the mechanisms controlling KARs and how KARs, in turn, regulate other proteins and pathways to influence synaptic function.

AB - Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in regulating neuronal excitability and network function in the brain. After being cloned in the 1990s, important progress has been made in understanding the mechanisms controlling the molecular and cellular properties of KARs, and the nature and extent of their regulation of wider neuronal activity. However, there have been significant recent advances towards understanding KAR trafficking through the secretory pathway, their precise synaptic positioning, and their roles in synaptic plasticity and disease. Here we provide an overview highlighting these new findings about the mechanisms controlling KARs and how KARs, in turn, regulate other proteins and pathways to influence synaptic function.

KW - Kainate receptors

KW - GluK2

KW - Trafficking

KW - RUSH

KW - Synaptic transmission

KW - Synaptic plasticity

KW - Humans

KW - Protein Transport/physiology

KW - Receptors, Kainic Acid/metabolism

KW - Animals

KW - Membrane Proteins/metabolism

KW - Neurons/metabolism

KW - Neuronal Plasticity/physiology

KW - Brain/metabolism

UR - http://www.scopus.com/inward/record.url?scp=85038623880&partnerID=8YFLogxK

U2 - 10.1007/s11064-017-2450-2

DO - 10.1007/s11064-017-2450-2

M3 - Review article

VL - 44

SP - 572

EP - 584

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

IS - 3

ER -