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Force-induced repolarization of an active crawler

Research output: Contribution to journalArticle

  • Pierre Recho
  • Thibaut Putelat
  • Lev Truskinovsky
Original languageEnglish
Article number033015
Number of pages10
JournalNew Journal of Physics
Volume21
Issue number3
DOIs
DateAccepted/In press - 11 Feb 2019
DatePublished (current) - 19 Mar 2019

Abstract

We develop a quantitative model of mechanical repolarization in a contraction-driven gel layer mimicking a crawling cell. We show that the force-velocity relations for such active crawlers exhibit multi-valuedness and hysteresis under both force and velocity control. The model predicts steady oscillations of cells attached to an elastic environment and offers a self-consistent mechanical explanation for all experimentally observed outcomes of cell collision tests.

    Research areas

  • active particle, cell crawling, active gel, cell oscillations, contact inhibition of locomotion, force-velocity relations

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