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Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats

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Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats. / Davies, Alexander S; Kim, Doyun; Park, Jeongrak; Lee, Jeong-Yun; Vang, Hue; Pickering, Anthony E.; Oh, Seog Bae.

In: PAIN, Vol. 160, No. 5, 01.05.2019, p. 1059-1069.

Research output: Contribution to journalArticle

Harvard

Davies, AS, Kim, D, Park, J, Lee, J-Y, Vang, H, Pickering, AE & Oh, SB 2019, 'Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats' PAIN, vol. 160, no. 5, pp. 1059-1069. https://doi.org/10.1097/j.pain.0000000000001482

APA

Davies, A. S., Kim, D., Park, J., Lee, J-Y., Vang, H., Pickering, A. E., & Oh, S. B. (2019). Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats. PAIN, 160(5), 1059-1069. https://doi.org/10.1097/j.pain.0000000000001482

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Author

Davies, Alexander S ; Kim, Doyun ; Park, Jeongrak ; Lee, Jeong-Yun ; Vang, Hue ; Pickering, Anthony E. ; Oh, Seog Bae. / Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats. In: PAIN. 2019 ; Vol. 160, No. 5. pp. 1059-1069.

Bibtex

@article{c15597a004d7474e8ca8643c140c8937,
title = "Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats",
abstract = "The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a strong motivator to feed, even in potentially hazardous circumstances (ie, threat of tissue damage). However, the neurobiological mechanisms of this endogenous reward-pain interaction are unclear. We have developed a simple model of sucrose drinking-induced analgesia in Sprague-Dawley rats (6-10 weeks old) and have undertaken a behavioral and pharmacological characterization using the Hargreaves' test of hind-paw thermal sensitivity. Our results reveal an acute, potent, and robust inhibitory effect of sucrose drinking on thermal nociceptive behaviour that unlike the phenomenon in neonates is independent of endogenous opioid signalling and does not seem to operate through classical descending inhibition of the spinal cord circuitry. Experience of sucrose drinking had a conditioning effect whereby the apparent expectancy of sucrose enabled water alone (in euvolemic animals) to elicit a short-lasting placebo-like analgesia. Sweet taste alone, however, was insufficient to elicit analgesia in adult rats intraorally perfused with sucrose. Instead, the sucrose analgesia phenomenon only appeared after conditioning by oral perfusion in chronically cannulated animals. This sucrose analgesia was completely prevented by systemic dosing of the endocannabinoid CB1 receptor antagonist rimonabant. These results indicate the presence of an endogenous supraspinal analgesic circuit that is recruited by the context of rewarding drinking and is dependent on endocannabinoid signalling. We propose that this hedonic sucrose-drinking model may be useful for further investigation of the supraspinal control of pain by appetite and reward.",
author = "Davies, {Alexander S} and Doyun Kim and Jeongrak Park and Jeong-Yun Lee and Hue Vang and Pickering, {Anthony E.} and Oh, {Seog Bae}",
year = "2019",
month = "5",
day = "1",
doi = "10.1097/j.pain.0000000000001482",
language = "English",
volume = "160",
pages = "1059--1069",
journal = "PAIN",
issn = "0304-3959",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats

AU - Davies, Alexander S

AU - Kim, Doyun

AU - Park, Jeongrak

AU - Lee, Jeong-Yun

AU - Vang, Hue

AU - Pickering, Anthony E.

AU - Oh, Seog Bae

PY - 2019/5/1

Y1 - 2019/5/1

N2 - The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a strong motivator to feed, even in potentially hazardous circumstances (ie, threat of tissue damage). However, the neurobiological mechanisms of this endogenous reward-pain interaction are unclear. We have developed a simple model of sucrose drinking-induced analgesia in Sprague-Dawley rats (6-10 weeks old) and have undertaken a behavioral and pharmacological characterization using the Hargreaves' test of hind-paw thermal sensitivity. Our results reveal an acute, potent, and robust inhibitory effect of sucrose drinking on thermal nociceptive behaviour that unlike the phenomenon in neonates is independent of endogenous opioid signalling and does not seem to operate through classical descending inhibition of the spinal cord circuitry. Experience of sucrose drinking had a conditioning effect whereby the apparent expectancy of sucrose enabled water alone (in euvolemic animals) to elicit a short-lasting placebo-like analgesia. Sweet taste alone, however, was insufficient to elicit analgesia in adult rats intraorally perfused with sucrose. Instead, the sucrose analgesia phenomenon only appeared after conditioning by oral perfusion in chronically cannulated animals. This sucrose analgesia was completely prevented by systemic dosing of the endocannabinoid CB1 receptor antagonist rimonabant. These results indicate the presence of an endogenous supraspinal analgesic circuit that is recruited by the context of rewarding drinking and is dependent on endocannabinoid signalling. We propose that this hedonic sucrose-drinking model may be useful for further investigation of the supraspinal control of pain by appetite and reward.

AB - The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a strong motivator to feed, even in potentially hazardous circumstances (ie, threat of tissue damage). However, the neurobiological mechanisms of this endogenous reward-pain interaction are unclear. We have developed a simple model of sucrose drinking-induced analgesia in Sprague-Dawley rats (6-10 weeks old) and have undertaken a behavioral and pharmacological characterization using the Hargreaves' test of hind-paw thermal sensitivity. Our results reveal an acute, potent, and robust inhibitory effect of sucrose drinking on thermal nociceptive behaviour that unlike the phenomenon in neonates is independent of endogenous opioid signalling and does not seem to operate through classical descending inhibition of the spinal cord circuitry. Experience of sucrose drinking had a conditioning effect whereby the apparent expectancy of sucrose enabled water alone (in euvolemic animals) to elicit a short-lasting placebo-like analgesia. Sweet taste alone, however, was insufficient to elicit analgesia in adult rats intraorally perfused with sucrose. Instead, the sucrose analgesia phenomenon only appeared after conditioning by oral perfusion in chronically cannulated animals. This sucrose analgesia was completely prevented by systemic dosing of the endocannabinoid CB1 receptor antagonist rimonabant. These results indicate the presence of an endogenous supraspinal analgesic circuit that is recruited by the context of rewarding drinking and is dependent on endocannabinoid signalling. We propose that this hedonic sucrose-drinking model may be useful for further investigation of the supraspinal control of pain by appetite and reward.

UR - http://www.scopus.com/inward/record.url?scp=85065080448&partnerID=8YFLogxK

U2 - 10.1097/j.pain.0000000000001482

DO - 10.1097/j.pain.0000000000001482

M3 - Article

VL - 160

SP - 1059

EP - 1069

JO - PAIN

T2 - PAIN

JF - PAIN

SN - 0304-3959

IS - 5

ER -