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Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation

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Heterogeneous and anisotropic integrative model of pulmonary veins : computational study of arrhythmogenic substrate for atrial fibrillation. / Aslanidi, Oleg V; Colman, Michael A; Varela, Marta; Zhao, Jichao; Smaill, Bruce H; Hancox, Jules C; Boyett, Mark R; Zhang, Henggui.

In: Interface Focus, Vol. 3, No. 2, 06.04.2013, p. 20120069.

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Aslanidi, OV, Colman, MA, Varela, M, Zhao, J, Smaill, BH, Hancox, JC, Boyett, MR & Zhang, H 2013, 'Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation' Interface Focus, vol. 3, no. 2, pp. 20120069. https://doi.org/10.1098/rsfs.2012.0069

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Aslanidi, Oleg V ; Colman, Michael A ; Varela, Marta ; Zhao, Jichao ; Smaill, Bruce H ; Hancox, Jules C ; Boyett, Mark R ; Zhang, Henggui. / Heterogeneous and anisotropic integrative model of pulmonary veins : computational study of arrhythmogenic substrate for atrial fibrillation. In: Interface Focus. 2013 ; Vol. 3, No. 2. pp. 20120069.

Bibtex

@article{f388fe7330084046bfafd8880d66da17,
title = "Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation",
abstract = "Mechanisms underlying the genesis of re-entrant substrate for the most common cardiac arrhythmia, atrial fibrillation (AF), are not well understood. In this study, we develop a multi-scale three-dimensional computational model that integrates cellular electrophysiology of the left atrium (LA) and pulmonary veins (PVs) with the respective tissue geometry and fibre orientation. The latter is reconstructed in unique detail from high-resolution (approx. 70 μm) contrast micro-computed tomography data. The model is used to explore the mechanisms of re-entry initiation and sustenance in the PV region, regarded as the primary source of high-frequency electrical activity in AF. Simulations of the three-dimensional model demonstrate that an initial break-down of normal electrical excitation wave-fronts can be caused by the electrical heterogeneity between the PVs and LA. High tissue anisotropy is then responsible for the slow conduction and generation of a re-entrant circuit near the PVs. Evidence of such circuits has been seen clinically in AF patients. Our computational study suggests that primarily the combination of electrical heterogeneity and conduction anisotropy between the PVs and LA tissues leads to the generation of a high-frequency (approx. 10 Hz) re-entrant source near the PV sleeves, thus providing new insights into the arrhythmogenic mechanisms of excitation waves underlying AF.",
author = "Aslanidi, {Oleg V} and Colman, {Michael A} and Marta Varela and Jichao Zhao and Smaill, {Bruce H} and Hancox, {Jules C} and Boyett, {Mark R} and Henggui Zhang",
year = "2013",
month = "4",
day = "6",
doi = "10.1098/rsfs.2012.0069",
language = "English",
volume = "3",
pages = "20120069",
journal = "Interface Focus",
issn = "2042-8898",
publisher = "The Royal Society",
number = "2",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Heterogeneous and anisotropic integrative model of pulmonary veins

T2 - Interface Focus

AU - Aslanidi, Oleg V

AU - Colman, Michael A

AU - Varela, Marta

AU - Zhao, Jichao

AU - Smaill, Bruce H

AU - Hancox, Jules C

AU - Boyett, Mark R

AU - Zhang, Henggui

PY - 2013/4/6

Y1 - 2013/4/6

N2 - Mechanisms underlying the genesis of re-entrant substrate for the most common cardiac arrhythmia, atrial fibrillation (AF), are not well understood. In this study, we develop a multi-scale three-dimensional computational model that integrates cellular electrophysiology of the left atrium (LA) and pulmonary veins (PVs) with the respective tissue geometry and fibre orientation. The latter is reconstructed in unique detail from high-resolution (approx. 70 μm) contrast micro-computed tomography data. The model is used to explore the mechanisms of re-entry initiation and sustenance in the PV region, regarded as the primary source of high-frequency electrical activity in AF. Simulations of the three-dimensional model demonstrate that an initial break-down of normal electrical excitation wave-fronts can be caused by the electrical heterogeneity between the PVs and LA. High tissue anisotropy is then responsible for the slow conduction and generation of a re-entrant circuit near the PVs. Evidence of such circuits has been seen clinically in AF patients. Our computational study suggests that primarily the combination of electrical heterogeneity and conduction anisotropy between the PVs and LA tissues leads to the generation of a high-frequency (approx. 10 Hz) re-entrant source near the PV sleeves, thus providing new insights into the arrhythmogenic mechanisms of excitation waves underlying AF.

AB - Mechanisms underlying the genesis of re-entrant substrate for the most common cardiac arrhythmia, atrial fibrillation (AF), are not well understood. In this study, we develop a multi-scale three-dimensional computational model that integrates cellular electrophysiology of the left atrium (LA) and pulmonary veins (PVs) with the respective tissue geometry and fibre orientation. The latter is reconstructed in unique detail from high-resolution (approx. 70 μm) contrast micro-computed tomography data. The model is used to explore the mechanisms of re-entry initiation and sustenance in the PV region, regarded as the primary source of high-frequency electrical activity in AF. Simulations of the three-dimensional model demonstrate that an initial break-down of normal electrical excitation wave-fronts can be caused by the electrical heterogeneity between the PVs and LA. High tissue anisotropy is then responsible for the slow conduction and generation of a re-entrant circuit near the PVs. Evidence of such circuits has been seen clinically in AF patients. Our computational study suggests that primarily the combination of electrical heterogeneity and conduction anisotropy between the PVs and LA tissues leads to the generation of a high-frequency (approx. 10 Hz) re-entrant source near the PV sleeves, thus providing new insights into the arrhythmogenic mechanisms of excitation waves underlying AF.

U2 - 10.1098/rsfs.2012.0069

DO - 10.1098/rsfs.2012.0069

M3 - Article

VL - 3

SP - 20120069

JO - Interface Focus

JF - Interface Focus

SN - 2042-8898

IS - 2

ER -