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How the complex pharmacology of the fentanyls contributes to their lethality

Research output: Contribution to journalEditorial

Original languageEnglish
Number of pages2
JournalAddiction
DOIs
DateAccepted/In press - 8 Mar 2019
DatePublished (current) - 17 Apr 2019

Abstract

Fentanyls as a class of drug have pharmacological properties that make them more likely to lead to overdose than other opioids. In addition to their high potency and rapid onset of action these drugs induce respiratory muscle stiffness making it difficult to breath, are less sensitive than heroin to naloxone reversal and may show reduced cross tolerance to other opioids.

    Research areas

  • fentanyl, heroin, muscle stiffness, naloxone, overdose, respiratory depression

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Wiley at https://onlinelibrary.wiley.com/doi/full/10.1111/add.14614 . Please refer to any applicable terms of use of the publisher.

    Final published version, 151 KB, PDF document

    Licence: CC BY

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