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Lactose as a "trojan horse" for quantum dot cell transport

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)810-814
Number of pages5
JournalAngewandte Chemie - International Edition
Volume53
Issue number3
DOIs
DatePublished - 13 Jan 2014

Abstract

A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a "Trojan horse" on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.

Additional information

Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

    Research areas

  • glycans, intracellular localization, multivalency, nanoparticles, quantum dots, GOLD NANOPARTICLES, PROTEIN, ENDOCYTOSIS, GLYCONANOPARTICLES, GLYCOBIOLOGY, NANOSCALE, MEDICINE, LIGANDS, BIOLOGY, FATE

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