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Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation

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Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation. / Mansell, Jason P; Brown, Judith; Knapp, Jonathan G; Faul, Charl F J; Blom, Ashley W.

In: eCells and Materials Journal, Vol. 9;23, 05.2012, p. 348 - 361.

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Mansell, JP, Brown, J, Knapp, JG, Faul, CFJ & Blom, AW 2012, 'Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation', eCells and Materials Journal, vol. 9;23, pp. 348 - 361.

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Mansell, Jason P ; Brown, Judith ; Knapp, Jonathan G ; Faul, Charl F J ; Blom, Ashley W. / Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation. In: eCells and Materials Journal. 2012 ; Vol. 9;23. pp. 348 - 361.

Bibtex

@article{6aa0101734754b0c9a2f859486d3b59c,
title = "Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation",
abstract = "Covalent modifications of titanium with small molecules known to promote human osteoblast maturation are especially attractive in developing superior biomaterials. An important step in securing competent bone formation at implant sites is promoting the formation of mature osteoblasts, either from committed pre-osteoblasts or from their mesenchymal progenitors. To this end our research has focussed on identifying molecules that enhance human osteoblast formation and maturation and to develop ways of covalently attaching these molecules to implant surfaces so that they are more likely to withstand the rigors of the implantation process whilst still retaining their bioactivity. Herein we report the novel production of lipid-functionalised titanium using lysophosphatidic acid or a related compound, (3S) 1-fluoro-3-hydroxy-4-butyl-1-phosphonate. Both lipids were especially effective at co-operating with calcitriol to promote human osteoblast maturation at these modified Ti surfaces in vitro. The novel findings presented offer enticing new developments towards the fabrication of next-generation implant devices with the potential to significantly enhance the osseointegration process and with it improvements in future prosthesis performance and longevity.",
author = "Mansell, {Jason P} and Judith Brown and Knapp, {Jonathan G} and Faul, {Charl F J} and Blom, {Ashley W}",
year = "2012",
month = "5",
language = "English",
volume = "9;23",
pages = "348 -- 361",
journal = "eCells and Materials Journal",
issn = "1473-2262",
publisher = "AO Research Institute",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation

AU - Mansell, Jason P

AU - Brown, Judith

AU - Knapp, Jonathan G

AU - Faul, Charl F J

AU - Blom, Ashley W

PY - 2012/5

Y1 - 2012/5

N2 - Covalent modifications of titanium with small molecules known to promote human osteoblast maturation are especially attractive in developing superior biomaterials. An important step in securing competent bone formation at implant sites is promoting the formation of mature osteoblasts, either from committed pre-osteoblasts or from their mesenchymal progenitors. To this end our research has focussed on identifying molecules that enhance human osteoblast formation and maturation and to develop ways of covalently attaching these molecules to implant surfaces so that they are more likely to withstand the rigors of the implantation process whilst still retaining their bioactivity. Herein we report the novel production of lipid-functionalised titanium using lysophosphatidic acid or a related compound, (3S) 1-fluoro-3-hydroxy-4-butyl-1-phosphonate. Both lipids were especially effective at co-operating with calcitriol to promote human osteoblast maturation at these modified Ti surfaces in vitro. The novel findings presented offer enticing new developments towards the fabrication of next-generation implant devices with the potential to significantly enhance the osseointegration process and with it improvements in future prosthesis performance and longevity.

AB - Covalent modifications of titanium with small molecules known to promote human osteoblast maturation are especially attractive in developing superior biomaterials. An important step in securing competent bone formation at implant sites is promoting the formation of mature osteoblasts, either from committed pre-osteoblasts or from their mesenchymal progenitors. To this end our research has focussed on identifying molecules that enhance human osteoblast formation and maturation and to develop ways of covalently attaching these molecules to implant surfaces so that they are more likely to withstand the rigors of the implantation process whilst still retaining their bioactivity. Herein we report the novel production of lipid-functionalised titanium using lysophosphatidic acid or a related compound, (3S) 1-fluoro-3-hydroxy-4-butyl-1-phosphonate. Both lipids were especially effective at co-operating with calcitriol to promote human osteoblast maturation at these modified Ti surfaces in vitro. The novel findings presented offer enticing new developments towards the fabrication of next-generation implant devices with the potential to significantly enhance the osseointegration process and with it improvements in future prosthesis performance and longevity.

M3 - Article

VL - 9;23

SP - 348

EP - 361

JO - eCells and Materials Journal

JF - eCells and Materials Journal

SN - 1473-2262

ER -