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Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)221-233
Number of pages13
JournalDevelopmental Cell
Volume40
Issue number3
DOIs
DateAccepted/In press - 4 Jan 2017
DatePublished (current) - 6 Feb 2017

Abstract

Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response.

    Research areas

  • Drosophila, macrophage, inflammation, apoptosis, development, wound, disease, migration, immunity

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Elsevier (Cell Press) at DOI: 10.1016/j.devcel.2017.01.001. Please refer to any applicable terms of use of the publisher.

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    Licence: CC BY

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