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Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis

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Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis. / Rodríguez-Arco, Laura; Kumar, B V V S Pavan; Li, Mei; Patil, Avinash J; Mann, Stephen.

In: Angewandte Chemie - International Edition, Vol. 58, No. 19, 06.05.2019, p. 6333-6337.

Research output: Contribution to journalArticle

Harvard

Rodríguez-Arco, L, Kumar, BVVSP, Li, M, Patil, AJ & Mann, S 2019, 'Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis', Angewandte Chemie - International Edition, vol. 58, no. 19, pp. 6333-6337. https://doi.org/10.1002/anie.201901469

APA

Rodríguez-Arco, L., Kumar, B. V. V. S. P., Li, M., Patil, A. J., & Mann, S. (2019). Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis. Angewandte Chemie - International Edition, 58(19), 6333-6337. https://doi.org/10.1002/anie.201901469

Vancouver

Rodríguez-Arco L, Kumar BVVSP, Li M, Patil AJ, Mann S. Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis. Angewandte Chemie - International Edition. 2019 May 6;58(19):6333-6337. https://doi.org/10.1002/anie.201901469

Author

Rodríguez-Arco, Laura ; Kumar, B V V S Pavan ; Li, Mei ; Patil, Avinash J ; Mann, Stephen. / Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis. In: Angewandte Chemie - International Edition. 2019 ; Vol. 58, No. 19. pp. 6333-6337.

Bibtex

@article{884172469a404d3189e9353bb6c417d5,
title = "Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis",
abstract = "Collective behaviour in mixed populations of synthetic protocells is an unexplored area of bottom-up synthetic biology. The dynamics of a model protocell community is exploited to modulate the function and higher-order behaviour of mixed populations of bioinorganic protocells in response to a process of artificial phagocytosis. Enzyme-loaded silica colloidosomes are spontaneously engulfed by magnetic Pickering emulsion (MPE) droplets containing complementary enzyme substrates to initiate a range of processes within the host/guest protocells. Specifically, catalase, lipase, or alkaline phosphatase-filled colloidosomes are used to trigger phagocytosis-induced buoyancy, membrane reconstruction, or hydrogelation, respectively, within the MPE droplets. The results highlight the potential for exploiting surface-contact interactions between different membrane-bounded droplets to transfer and co-locate discrete chemical packages (artificial organelles) in communities of synthetic protocells.",
keywords = "colloids, emulsions, enzymes, microcapsules, protocells, SYNTHETIC BIOLOGY",
author = "Laura Rodr{\'i}guez-Arco and Kumar, {B V V S Pavan} and Mei Li and Patil, {Avinash J} and Stephen Mann",
note = "{\circledC} 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.",
year = "2019",
month = "5",
day = "6",
doi = "10.1002/anie.201901469",
language = "English",
volume = "58",
pages = "6333--6337",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "Wiley-VCH Verlag",
number = "19",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis

AU - Rodríguez-Arco, Laura

AU - Kumar, B V V S Pavan

AU - Li, Mei

AU - Patil, Avinash J

AU - Mann, Stephen

N1 - © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

PY - 2019/5/6

Y1 - 2019/5/6

N2 - Collective behaviour in mixed populations of synthetic protocells is an unexplored area of bottom-up synthetic biology. The dynamics of a model protocell community is exploited to modulate the function and higher-order behaviour of mixed populations of bioinorganic protocells in response to a process of artificial phagocytosis. Enzyme-loaded silica colloidosomes are spontaneously engulfed by magnetic Pickering emulsion (MPE) droplets containing complementary enzyme substrates to initiate a range of processes within the host/guest protocells. Specifically, catalase, lipase, or alkaline phosphatase-filled colloidosomes are used to trigger phagocytosis-induced buoyancy, membrane reconstruction, or hydrogelation, respectively, within the MPE droplets. The results highlight the potential for exploiting surface-contact interactions between different membrane-bounded droplets to transfer and co-locate discrete chemical packages (artificial organelles) in communities of synthetic protocells.

AB - Collective behaviour in mixed populations of synthetic protocells is an unexplored area of bottom-up synthetic biology. The dynamics of a model protocell community is exploited to modulate the function and higher-order behaviour of mixed populations of bioinorganic protocells in response to a process of artificial phagocytosis. Enzyme-loaded silica colloidosomes are spontaneously engulfed by magnetic Pickering emulsion (MPE) droplets containing complementary enzyme substrates to initiate a range of processes within the host/guest protocells. Specifically, catalase, lipase, or alkaline phosphatase-filled colloidosomes are used to trigger phagocytosis-induced buoyancy, membrane reconstruction, or hydrogelation, respectively, within the MPE droplets. The results highlight the potential for exploiting surface-contact interactions between different membrane-bounded droplets to transfer and co-locate discrete chemical packages (artificial organelles) in communities of synthetic protocells.

KW - colloids

KW - emulsions

KW - enzymes

KW - microcapsules

KW - protocells

KW - SYNTHETIC BIOLOGY

UR - http://www.scopus.com/inward/record.url?scp=85063910324&partnerID=8YFLogxK

U2 - 10.1002/anie.201901469

DO - 10.1002/anie.201901469

M3 - Article

VL - 58

SP - 6333

EP - 6337

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 19

ER -