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Motor–cargo adaptors at the organelle–cytoskeleton interface

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume59
Early online date2 Apr 2019
DOIs
DateAccepted/In press - 26 Feb 2019
DateE-pub ahead of print - 2 Apr 2019
DatePublished (current) - 1 Aug 2019

Abstract

Cytoskeletal motors of the dynein, kinesin and myosin superfamilies maintain and adapt subcellular organelle organization to meet functional demands and support the vesicular transport of material between organelles. These motors require the capacity to specifically recognize the vesicle/organelle to be transported and are capable of selective recognition of multiple cargo. Recent studies have begun to uncover the molecular basis for motor recruitment and have highlighted the role of organelle-associated ‘cargo-adaptor’ proteins in cellular transport. These adaptors possess sequences and/or structural features that enable both motor recruitment and activation from regulated, inactive, states to enable motility on the cytoskeleton. Motor–cargo adaptor interactions define a key organelle–cytoskeleton interface, acting as crucial regulatory hubs to enable the cell to finely control membrane trafficking and organelle dynamics. Understanding the molecular basis of these interactions may offer new opportunities to control and manipulate cytoskeletal and organelle dynamics for the development of new research tools and potentially therapeutics.

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    Rights statement: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.ceb.2019.02.010 . Please refer to any applicable terms of use of the publisher.

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    Licence: CC BY-NC-ND

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