Skip to content

Neighborhood Characteristics at Birth and Positive and Negative Psychotic Symptoms in Adolescence: Findings From the ALSPAC Birth Cohort

Research output: Contribution to journalArticle

Standard

Neighborhood Characteristics at Birth and Positive and Negative Psychotic Symptoms in Adolescence : Findings From the ALSPAC Birth Cohort. / Solmi, Francesca; Zammit, Stan; Kirkbride, James B.

In: Schizophrenia Bulletin, 05.06.2019.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Bibtex

@article{a8ca32f34ca14daab09e40472a620d9a,
title = "Neighborhood Characteristics at Birth and Positive and Negative Psychotic Symptoms in Adolescence: Findings From the ALSPAC Birth Cohort",
abstract = "Background: Urban birth is associated with risk of non-affective psychoses, but the association with subclinical positive and negative symptoms is less clear, despite emerging evidence. Further the extent to which these findings are confounded by polygenic risk for schizophrenia (PRS) is also unknown. Methods: Using data from the Avon Longitudinal Study of Parents and Children, linked to census geographical indicators, we examined whether various indices of urbanicity at birth were associated with negative and positive psychotic symptoms at age 16 and 18 years, respectively. We used logistic regression models, controlling for child’s ethnicity, maternal age, education, marital status, social class, depressive symptoms, other neighbourhood exposures, and, in a sub-sample of children of white ethnicity (N=10,283), PRS for schizophrenia. Results: Amongst 11,879 adolescents, those born in the most densely populated tertile had greater odds of reporting positive psychotic experiences, after multivariable adjustment (odds ratio (OR): 1.57, 95{\%} confidence intervals (CI): 1.14 – 2.17). Adolescents born in the most socially fragmented neighbourhoods had greater odds of negative symptoms, after multivariable adjustment (OR: 1.43, 95{\%}CI: 1.06 – 1.85). Although we found that greater schizophrenia PRS were associated with an increased risk of being born in more deprived and fragmented (bot not more densely populated areas), these associations were not confounded by PRS.Interpretation: Birth into more densely populated and socially fragmented environments increased risk of positive and negative psychotic phenomena in adolescence, respectively, suggesting that different forms of neighbourhood social adversity may impinge on different psychopathophysiologies associated with the clinical expression of psychosis.",
keywords = "psychotic experiences, negative symptoms, neighborhood, cohort study, ALSPAC, polygenic risk scores",
author = "Francesca Solmi and Stan Zammit and Kirkbride, {James B}",
year = "2019",
month = "6",
day = "5",
doi = "10.1093/schbul/sbz049",
language = "English",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Neighborhood Characteristics at Birth and Positive and Negative Psychotic Symptoms in Adolescence

T2 - Findings From the ALSPAC Birth Cohort

AU - Solmi, Francesca

AU - Zammit, Stan

AU - Kirkbride, James B

PY - 2019/6/5

Y1 - 2019/6/5

N2 - Background: Urban birth is associated with risk of non-affective psychoses, but the association with subclinical positive and negative symptoms is less clear, despite emerging evidence. Further the extent to which these findings are confounded by polygenic risk for schizophrenia (PRS) is also unknown. Methods: Using data from the Avon Longitudinal Study of Parents and Children, linked to census geographical indicators, we examined whether various indices of urbanicity at birth were associated with negative and positive psychotic symptoms at age 16 and 18 years, respectively. We used logistic regression models, controlling for child’s ethnicity, maternal age, education, marital status, social class, depressive symptoms, other neighbourhood exposures, and, in a sub-sample of children of white ethnicity (N=10,283), PRS for schizophrenia. Results: Amongst 11,879 adolescents, those born in the most densely populated tertile had greater odds of reporting positive psychotic experiences, after multivariable adjustment (odds ratio (OR): 1.57, 95% confidence intervals (CI): 1.14 – 2.17). Adolescents born in the most socially fragmented neighbourhoods had greater odds of negative symptoms, after multivariable adjustment (OR: 1.43, 95%CI: 1.06 – 1.85). Although we found that greater schizophrenia PRS were associated with an increased risk of being born in more deprived and fragmented (bot not more densely populated areas), these associations were not confounded by PRS.Interpretation: Birth into more densely populated and socially fragmented environments increased risk of positive and negative psychotic phenomena in adolescence, respectively, suggesting that different forms of neighbourhood social adversity may impinge on different psychopathophysiologies associated with the clinical expression of psychosis.

AB - Background: Urban birth is associated with risk of non-affective psychoses, but the association with subclinical positive and negative symptoms is less clear, despite emerging evidence. Further the extent to which these findings are confounded by polygenic risk for schizophrenia (PRS) is also unknown. Methods: Using data from the Avon Longitudinal Study of Parents and Children, linked to census geographical indicators, we examined whether various indices of urbanicity at birth were associated with negative and positive psychotic symptoms at age 16 and 18 years, respectively. We used logistic regression models, controlling for child’s ethnicity, maternal age, education, marital status, social class, depressive symptoms, other neighbourhood exposures, and, in a sub-sample of children of white ethnicity (N=10,283), PRS for schizophrenia. Results: Amongst 11,879 adolescents, those born in the most densely populated tertile had greater odds of reporting positive psychotic experiences, after multivariable adjustment (odds ratio (OR): 1.57, 95% confidence intervals (CI): 1.14 – 2.17). Adolescents born in the most socially fragmented neighbourhoods had greater odds of negative symptoms, after multivariable adjustment (OR: 1.43, 95%CI: 1.06 – 1.85). Although we found that greater schizophrenia PRS were associated with an increased risk of being born in more deprived and fragmented (bot not more densely populated areas), these associations were not confounded by PRS.Interpretation: Birth into more densely populated and socially fragmented environments increased risk of positive and negative psychotic phenomena in adolescence, respectively, suggesting that different forms of neighbourhood social adversity may impinge on different psychopathophysiologies associated with the clinical expression of psychosis.

KW - psychotic experiences

KW - negative symptoms

KW - neighborhood

KW - cohort study

KW - ALSPAC

KW - polygenic risk scores

U2 - 10.1093/schbul/sbz049

DO - 10.1093/schbul/sbz049

M3 - Article

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

M1 - sbz049

ER -