Skip to content

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Research output: Contribution to journalArticle

  • Yingchang Lu
  • Felix R Day
  • Stefan Gustafsson
  • Martin L Buchkovich
  • Jianbo Na
  • Veronique Bataille
  • Diana L Cousminer
  • Zari Dastani
  • Alexander W Drong
  • Tõnu Esko
  • David M Evans
  • Mario Falchi
  • Mary F Feitosa
  • Teresa Ferreira
  • Åsa K Hedman
  • Robin Haring
  • Pirro G Hysi
  • Mark M Iles
  • Anne E Justice
  • Stavroula Kanoni
  • Vasiliki Lagou
  • Rui Li
  • Xin Li
  • Adam Locke
  • Chen Lu
  • Reedik Mägi
  • John R B Perry
  • Tune H Pers
  • Qibin Qi
  • Marianna Sanna
  • Ellen M Schmidt
  • William R Scott
  • Dmitry Shungin
  • Alexander Teumer
  • Anna A E Vinkhuyzen
  • Ryan W Walker
  • Harm-Jan Westra
  • Mingfeng Zhang
  • Weihua Zhang
  • Jing Hua Zhao
  • Zhihong Zhu
  • Uzma Afzal
  • Tarunveer Singh Ahluwalia
  • Stephan J L Bakker
  • Claire Bellis
  • Amélie Bonnefond
  • Katja Borodulin
  • Aron S Buchman
  • Tommy Cederholm
  • Audrey C Choh
  • Hyung Jin Choi
  • Joanne E Curran
  • Lisette C P G M de Groot
  • Philip L De Jager
  • Rosalie A M Dhonukshe-Rutten
  • Anke W Enneman
  • Elodie Eury
  • Daniel S Evans
  • Tom Forsen
  • Nele Friedrich
  • Frédéric Fumeron
  • Melissa E Garcia
  • Simone Gärtner
  • Bok-Ghee Han
  • Aki S Havulinna
  • Caroline Hayward
  • Dena Hernandez
  • Hans Hillege
  • Till Ittermann
  • Jack W Kent
  • Ivana Kolcic
  • Tiina Laatikainen
  • Jari Lahti
  • Irene Mateo Leach
  • Christine G Lee
  • Jong-Young Lee
  • Tian Liu
  • Youfang Liu
  • Stéphane Lobbens
  • Marie Loh
  • Leo-Pekka Lyytikäinen
  • Carolina Medina-Gomez
  • Karl Michaëlsson
  • Mike A Nalls
  • Carrie M Nielson
  • Laticia Oozageer
  • Laura Pascoe
  • Lavinia Paternosterhttp://orcid.org/0000-0003-2514-0889
  • Ozren Polašek
  • Samuli Ripatti
  • Mark A Sarzynski
  • Chan Soo Shin
  • Nina Smolej Narančić
  • Dominik Spira
  • Priya Srikanth
  • Elisabeth Steinhagen-Thiessen
  • Yun Ju Sung
  • Karin M A Swart
  • Leena Taittonen
  • Toshiko Tanaka
  • Emmi Tikkanen
  • Nathalie van der Velde
  • Natasja M van Schoor
  • Niek Verweij
  • Alan F Wright
  • Lei Yu
  • Joseph M Zmuda
  • Niina Eklund
  • Terrence Forrester
  • Niels Grarup
  • Anne U Jackson
  • Kati Kristiansson
  • Teemu Kuulasmaa
  • Johanna Kuusisto
  • Peter Lichtner
  • Jian'an Luan
  • Anubha Mahajan
  • Satu Männistö
  • Cameron D Palmer
  • Janina S Ried
  • Robert A Scott
  • Alena Stancáková
  • Peter J Wagner
  • Ayse Demirkan
  • Angela Döring
  • Vilmundur Gudnason
  • Douglas P Kiel
  • Brigitte Kühnel
  • Massimo Mangino
  • Barbara Mcknight
  • Cristina Menni
  • Jeffrey R O'Connell
  • Ben A Oostra
  • Alan R Shuldiner
  • Kijoung Song
  • Liesbeth Vandenput
  • Cornelia M van Duijn
  • Peter Vollenweider
  • Charles C White
  • Michael Boehnke
  • Yvonne Boettcher
  • Richard S Cooper
  • Nita G Forouhi
  • Christian Gieger
  • Harald Grallert
  • Aroon Hingorani
  • Torben Jørgensen
  • Pekka Jousilahti
  • Mika J Kivimaki
  • Meena Kumari
  • Markku Laakso
  • Claudia Langenberg
  • Allan Linneberg
  • Amy Luke
  • Colin A Mckenzie
  • Aarno Palotie
  • Oluf Pedersen
  • Annette Peters
  • Konstantin Strauch
  • Bamidele O Tayo
  • Nicholas J Wareham
  • David A Bennett
  • Lars Bertram
  • John Blangero
  • Matthias Blüher
  • Claude Bouchard
  • Harry Campbell
  • Nam H Cho
  • Steven R Cummings
  • Stefan A Czerwinski
  • Ilja Demuth
  • Rahel Eckardt
  • Johan G Eriksson
  • Luigi Ferrucci
  • Oscar H Franco
  • Philippe Froguel
  • Ron T Gansevoort
  • Torben Hansen
  • Tamara B Harris
  • Nicholas Hastie
  • Markku Heliövaara
  • Albert Hofman
  • Joanne M Jordan
  • Antti Jula
  • Mika Kähönen
  • Eero Kajantie
  • Paul B Knekt
  • Seppo Koskinen
  • Peter Kovacs
  • Terho Lehtimäki
  • Lars Lind
  • Yongmei Liu
  • Eric S Orwoll
  • Clive Osmond
  • Markus Perola
  • Louis Pérusse
  • Olli T Raitakari
  • Tuomo Rankinen
  • Dabeeru C Rao
  • Treva K Rice
  • Fernando Rivadeneira
  • Igor Rudan
  • Veikko Salomaa
  • Thorkild Sorensen
  • Michael Stumvoll
  • Anke Tönjes
  • Bradford Towne
  • Gregory J Tranah
  • Angelo Tremblay
  • André G Uitterlinden
  • Pim van der Harst
  • Erkki Vartiainen
  • Jorma S Viikari
  • Veronique Vitart
  • Marie-Claude Vohl
  • Henry Völzke
  • Mark Walker
  • Henri Wallaschofski
  • Sarah Wild
  • James F Wilson
  • Loïc Yengo
  • D Timothy Bishop
  • Ingrid B Borecki
  • John C Chambers
  • L Adrienne Cupples
  • Abbas Dehghan
  • Panos Deloukas
  • Ghazaleh Fatemifar
  • Caroline Fox
  • Terrence S Furey
  • Lude Franke
  • Jiali Han
  • David J Hunter
  • Juha Karjalainen
  • Fredrik Karpe
  • Robert C Kaplan
  • Jaspal S Kooner
  • Mark I McCarthy
  • Joanne M Murabito
  • Andrew P Morris
  • Julia A N Bishop
  • Kari E North
  • Claes Ohlsson
  • Ken K Ong
  • Inga Prokopenko
  • J Brent Richards
  • Eric E Schadt
  • Tim D Spector
  • Elisabeth Widén
  • Cristen J Willer
  • Jian Yang
  • Erik Ingelsson
  • Karen L Mohlke
  • Joel N Hirschhorn
  • John Andrew Pospisilik
  • M Carola Zillikens
  • Cecilia Lindgren
  • Tuomas Oskari Kilpeläinen
  • Ruth J F Loos
Original languageEnglish
Article number10495
Number of pages15
JournalNature Communications
Volume7
DOIs
DateAccepted/In press - 16 Dec 2015
DatePublished (current) - 1 Feb 2016

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

    Research areas

  • Biological sciences, Genetics

Download statistics

No data available

Documents

Documents

  • ncomms10495

    Rights statement: This is the final published version of the article (version of record). It first appeared online via Nature at http://www.nature.com/ncomms/2016/160201/ncomms10495/full/ncomms10495.html. Please refer to any applicable terms of use of the publisher.

    Final published version, 1 MB, PDF-document

    Licence: CC BY

DOI

View research connections

Related faculties, schools or groups