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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. / Lu, Yingchang; Day, Felix R; Gustafsson, Stefan; Buchkovich, Martin L; Na, Jianbo; Bataille, Veronique; Cousminer, Diana L; Dastani, Zari; Drong, Alexander W; Esko, Tõnu; Evans, David M; Falchi, Mario; Feitosa, Mary F; Ferreira, Teresa; Hedman, Åsa K; Haring, Robin; Hysi, Pirro G; Iles, Mark M; Justice, Anne E; Kanoni, Stavroula; Lagou, Vasiliki; Li, Rui; Li, Xin; Locke, Adam; Lu, Chen; Mägi, Reedik; Perry, John R B; Pers, Tune H; Qi, Qibin; Sanna, Marianna; Schmidt, Ellen M; Scott, William R; Shungin, Dmitry; Teumer, Alexander; Vinkhuyzen, Anna A E; Walker, Ryan W; Westra, Harm-Jan; Zhang, Mingfeng; Zhang, Weihua; Zhao, Jing Hua; Zhu, Zhihong; Afzal, Uzma; Ahluwalia, Tarunveer Singh; Bakker, Stephan J L; Bellis, Claire; Bonnefond, Amélie; Borodulin, Katja; Buchman, Aron S; Cederholm, Tommy; Choh, Audrey C; Choi, Hyung Jin; Curran, Joanne E; de Groot, Lisette C P G M; De Jager, Philip L; Dhonukshe-Rutten, Rosalie A M; Enneman, Anke W; Eury, Elodie; Evans, Daniel S; Forsen, Tom; Friedrich, Nele; Fumeron, Frédéric; Garcia, Melissa E; Gärtner, Simone; Han, Bok-Ghee; Havulinna, Aki S; Hayward, Caroline; Hernandez, Dena; Hillege, Hans; Ittermann, Till; Kent, Jack W; Kolcic, Ivana; Laatikainen, Tiina; Lahti, Jari; Mateo Leach, Irene; Lee, Christine G; Lee, Jong-Young; Liu, Tian; Liu, Youfang; Lobbens, Stéphane; Loh, Marie; Lyytikäinen, Leo-Pekka; Medina-Gomez, Carolina; Michaëlsson, Karl; Nalls, Mike A; Nielson, Carrie M; Oozageer, Laticia; Pascoe, Laura; Paternoster, Lavinia; Polašek, Ozren; Ripatti, Samuli; Sarzynski, Mark A; Shin, Chan Soo; Narančić, Nina Smolej; Spira, Dominik; Srikanth, Priya; Steinhagen-Thiessen, Elisabeth; Sung, Yun Ju; Swart, Karin M A; Taittonen, Leena; Tanaka, Toshiko; Tikkanen, Emmi; van der Velde, Nathalie; van Schoor, Natasja M; Verweij, Niek; Wright, Alan F; Yu, Lei; Zmuda, Joseph M; Eklund, Niina; Forrester, Terrence; Grarup, Niels; Jackson, Anne U; Kristiansson, Kati; Kuulasmaa, Teemu; Kuusisto, Johanna; Lichtner, Peter; Luan, Jian'an; Mahajan, Anubha; Männistö, Satu; Palmer, Cameron D; Ried, Janina S; Scott, Robert A; Stancáková, Alena; Wagner, Peter J; Demirkan, Ayse; Döring, Angela; Gudnason, Vilmundur; Kiel, Douglas P; Kühnel, Brigitte; Mangino, Massimo; Mcknight, Barbara; Menni, Cristina; O'Connell, Jeffrey R; Oostra, Ben A; Shuldiner, Alan R; Song, Kijoung; Vandenput, Liesbeth; van Duijn, Cornelia M; Vollenweider, Peter; White, Charles C; Boehnke, Michael; Boettcher, Yvonne; Cooper, Richard S; Forouhi, Nita G; Gieger, Christian; Grallert, Harald; Hingorani, Aroon; Jørgensen, Torben; Jousilahti, Pekka; Kivimaki, Mika J; Kumari, Meena; Laakso, Markku; Langenberg, Claudia; Linneberg, Allan; Luke, Amy; Mckenzie, Colin A; Palotie, Aarno; Pedersen, Oluf; Peters, Annette; Strauch, Konstantin; Tayo, Bamidele O; Wareham, Nicholas J; Bennett, David A; Bertram, Lars; Blangero, John; Blüher, Matthias; Bouchard, Claude; Campbell, Harry; Cho, Nam H; Cummings, Steven R; Czerwinski, Stefan A; Demuth, Ilja; Eckardt, Rahel; Eriksson, Johan G; Ferrucci, Luigi; Franco, Oscar H; Froguel, Philippe; Gansevoort, Ron T; Hansen, Torben; Harris, Tamara B; Hastie, Nicholas; Heliövaara, Markku; Hofman, Albert; Jordan, Joanne M; Jula, Antti; Kähönen, Mika; Kajantie, Eero; Knekt, Paul B; Koskinen, Seppo; Kovacs, Peter; Lehtimäki, Terho; Lind, Lars; Liu, Yongmei; Orwoll, Eric S; Osmond, Clive; Perola, Markus; Pérusse, Louis; Raitakari, Olli T; Rankinen, Tuomo; Rao, Dabeeru C; Rice, Treva K; Rivadeneira, Fernando; Rudan, Igor; Salomaa, Veikko; Sorensen, Thorkild; Stumvoll, Michael; Tönjes, Anke; Towne, Bradford; Tranah, Gregory J; Tremblay, Angelo; Uitterlinden, André G; van der Harst, Pim; Vartiainen, Erkki; Viikari, Jorma S; Vitart, Veronique; Vohl, Marie-Claude; Völzke, Henry; Walker, Mark; Wallaschofski, Henri; Wild, Sarah; Wilson, James F; Yengo, Loïc; Bishop, D Timothy; Borecki, Ingrid B; Chambers, John C; Cupples, L Adrienne; Dehghan, Abbas; Deloukas, Panos; Fatemifar, Ghazaleh; Fox, Caroline; Furey, Terrence S; Franke, Lude; Han, Jiali; Hunter, David J; Karjalainen, Juha; Karpe, Fredrik; Kaplan, Robert C; Kooner, Jaspal S; McCarthy, Mark I; Murabito, Joanne M; Morris, Andrew P; Bishop, Julia A N; North, Kari E; Ohlsson, Claes; Ong, Ken K; Prokopenko, Inga; Richards, J Brent; Schadt, Eric E; Spector, Tim D; Widén, Elisabeth; Willer, Cristen J; Yang, Jian; Ingelsson, Erik; Mohlke, Karen L; Hirschhorn, Joel N; Pospisilik, John Andrew; Zillikens, M Carola; Lindgren, Cecilia; Kilpeläinen, Tuomas Oskari; Loos, Ruth J F.

In: Nature Communications, Vol. 7, 10495, 01.02.2016.

Research output: Contribution to journalArticle

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Lu, Y, Day, FR, Gustafsson, S, Buchkovich, ML, Na, J, Bataille, V, Cousminer, DL, Dastani, Z, Drong, AW, Esko, T, Evans, DM, Falchi, M, Feitosa, MF, Ferreira, T, Hedman, ÅK, Haring, R, Hysi, PG, Iles, MM, Justice, AE, Kanoni, S, Lagou, V, Li, R, Li, X, Locke, A, Lu, C, Mägi, R, Perry, JRB, Pers, TH, Qi, Q, Sanna, M, Schmidt, EM, Scott, WR, Shungin, D, Teumer, A, Vinkhuyzen, AAE, Walker, RW, Westra, H-J, Zhang, M, Zhang, W, Zhao, JH, Zhu, Z, Afzal, U, Ahluwalia, TS, Bakker, SJL, Bellis, C, Bonnefond, A, Borodulin, K, Buchman, AS, Cederholm, T, Choh, AC, Choi, HJ, Curran, JE, de Groot, LCPGM, De Jager, PL, Dhonukshe-Rutten, RAM, Enneman, AW, Eury, E, Evans, DS, Forsen, T, Friedrich, N, Fumeron, F, Garcia, ME, Gärtner, S, Han, B-G, Havulinna, AS, Hayward, C, Hernandez, D, Hillege, H, Ittermann, T, Kent, JW, Kolcic, I, Laatikainen, T, Lahti, J, Mateo Leach, I, Lee, CG, Lee, J-Y, Liu, T, Liu, Y, Lobbens, S, Loh, M, Lyytikäinen, L-P, Medina-Gomez, C, Michaëlsson, K, Nalls, MA, Nielson, CM, Oozageer, L, Pascoe, L, Paternoster, L, Polašek, O, Ripatti, S, Sarzynski, MA, Shin, CS, Narančić, NS, Spira, D, Srikanth, P, Steinhagen-Thiessen, E, Sung, YJ, Swart, KMA, Taittonen, L, Tanaka, T, Tikkanen, E, van der Velde, N, van Schoor, NM, Verweij, N, Wright, AF, Yu, L, Zmuda, JM, Eklund, N, Forrester, T, Grarup, N, Jackson, AU, Kristiansson, K, Kuulasmaa, T, Kuusisto, J, Lichtner, P, Luan, J, Mahajan, A, Männistö, S, Palmer, CD, Ried, JS, Scott, RA, Stancáková, A, Wagner, PJ, Demirkan, A, Döring, A, Gudnason, V, Kiel, DP, Kühnel, B, Mangino, M, Mcknight, B, Menni, C, O'Connell, JR, Oostra, BA, Shuldiner, AR, Song, K, Vandenput, L, van Duijn, CM, Vollenweider, P, White, CC, Boehnke, M, Boettcher, Y, Cooper, RS, Forouhi, NG, Gieger, C, Grallert, H, Hingorani, A, Jørgensen, T, Jousilahti, P, Kivimaki, MJ, Kumari, M, Laakso, M, Langenberg, C, Linneberg, A, Luke, A, Mckenzie, CA, Palotie, A, Pedersen, O, Peters, A, Strauch, K, Tayo, BO, Wareham, NJ, Bennett, DA, Bertram, L, Blangero, J, Blüher, M, Bouchard, C, Campbell, H, Cho, NH, Cummings, SR, Czerwinski, SA, Demuth, I, Eckardt, R, Eriksson, JG, Ferrucci, L, Franco, OH, Froguel, P, Gansevoort, RT, Hansen, T, Harris, TB, Hastie, N, Heliövaara, M, Hofman, A, Jordan, JM, Jula, A, Kähönen, M, Kajantie, E, Knekt, PB, Koskinen, S, Kovacs, P, Lehtimäki, T, Lind, L, Liu, Y, Orwoll, ES, Osmond, C, Perola, M, Pérusse, L, Raitakari, OT, Rankinen, T, Rao, DC, Rice, TK, Rivadeneira, F, Rudan, I, Salomaa, V, Sorensen, T, Stumvoll, M, Tönjes, A, Towne, B, Tranah, GJ, Tremblay, A, Uitterlinden, AG, van der Harst, P, Vartiainen, E, Viikari, JS, Vitart, V, Vohl, M-C, Völzke, H, Walker, M, Wallaschofski, H, Wild, S, Wilson, JF, Yengo, L, Bishop, DT, Borecki, IB, Chambers, JC, Cupples, LA, Dehghan, A, Deloukas, P, Fatemifar, G, Fox, C, Furey, TS, Franke, L, Han, J, Hunter, DJ, Karjalainen, J, Karpe, F, Kaplan, RC, Kooner, JS, McCarthy, MI, Murabito, JM, Morris, AP, Bishop, JAN, North, KE, Ohlsson, C, Ong, KK, Prokopenko, I, Richards, JB, Schadt, EE, Spector, TD, Widén, E, Willer, CJ, Yang, J, Ingelsson, E, Mohlke, KL, Hirschhorn, JN, Pospisilik, JA, Zillikens, MC, Lindgren, C, Kilpeläinen, TO & Loos, RJF 2016, 'New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk', Nature Communications, vol. 7, 10495. https://doi.org/10.1038/ncomms10495

APA

Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V., ... Loos, R. J. F. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7, [10495]. https://doi.org/10.1038/ncomms10495

Vancouver

Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V et al. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications. 2016 Feb 1;7. 10495. https://doi.org/10.1038/ncomms10495

Author

Lu, Yingchang ; Day, Felix R ; Gustafsson, Stefan ; Buchkovich, Martin L ; Na, Jianbo ; Bataille, Veronique ; Cousminer, Diana L ; Dastani, Zari ; Drong, Alexander W ; Esko, Tõnu ; Evans, David M ; Falchi, Mario ; Feitosa, Mary F ; Ferreira, Teresa ; Hedman, Åsa K ; Haring, Robin ; Hysi, Pirro G ; Iles, Mark M ; Justice, Anne E ; Kanoni, Stavroula ; Lagou, Vasiliki ; Li, Rui ; Li, Xin ; Locke, Adam ; Lu, Chen ; Mägi, Reedik ; Perry, John R B ; Pers, Tune H ; Qi, Qibin ; Sanna, Marianna ; Schmidt, Ellen M ; Scott, William R ; Shungin, Dmitry ; Teumer, Alexander ; Vinkhuyzen, Anna A E ; Walker, Ryan W ; Westra, Harm-Jan ; Zhang, Mingfeng ; Zhang, Weihua ; Zhao, Jing Hua ; Zhu, Zhihong ; Afzal, Uzma ; Ahluwalia, Tarunveer Singh ; Bakker, Stephan J L ; Bellis, Claire ; Bonnefond, Amélie ; Borodulin, Katja ; Buchman, Aron S ; Cederholm, Tommy ; Choh, Audrey C ; Choi, Hyung Jin ; Curran, Joanne E ; de Groot, Lisette C P G M ; De Jager, Philip L ; Dhonukshe-Rutten, Rosalie A M ; Enneman, Anke W ; Eury, Elodie ; Evans, Daniel S ; Forsen, Tom ; Friedrich, Nele ; Fumeron, Frédéric ; Garcia, Melissa E ; Gärtner, Simone ; Han, Bok-Ghee ; Havulinna, Aki S ; Hayward, Caroline ; Hernandez, Dena ; Hillege, Hans ; Ittermann, Till ; Kent, Jack W ; Kolcic, Ivana ; Laatikainen, Tiina ; Lahti, Jari ; Mateo Leach, Irene ; Lee, Christine G ; Lee, Jong-Young ; Liu, Tian ; Liu, Youfang ; Lobbens, Stéphane ; Loh, Marie ; Lyytikäinen, Leo-Pekka ; Medina-Gomez, Carolina ; Michaëlsson, Karl ; Nalls, Mike A ; Nielson, Carrie M ; Oozageer, Laticia ; Pascoe, Laura ; Paternoster, Lavinia ; Polašek, Ozren ; Ripatti, Samuli ; Sarzynski, Mark A ; Shin, Chan Soo ; Narančić, Nina Smolej ; Spira, Dominik ; Srikanth, Priya ; Steinhagen-Thiessen, Elisabeth ; Sung, Yun Ju ; Swart, Karin M A ; Taittonen, Leena ; Tanaka, Toshiko ; Tikkanen, Emmi ; van der Velde, Nathalie ; van Schoor, Natasja M ; Verweij, Niek ; Wright, Alan F ; Yu, Lei ; Zmuda, Joseph M ; Eklund, Niina ; Forrester, Terrence ; Grarup, Niels ; Jackson, Anne U ; Kristiansson, Kati ; Kuulasmaa, Teemu ; Kuusisto, Johanna ; Lichtner, Peter ; Luan, Jian'an ; Mahajan, Anubha ; Männistö, Satu ; Palmer, Cameron D ; Ried, Janina S ; Scott, Robert A ; Stancáková, Alena ; Wagner, Peter J ; Demirkan, Ayse ; Döring, Angela ; Gudnason, Vilmundur ; Kiel, Douglas P ; Kühnel, Brigitte ; Mangino, Massimo ; Mcknight, Barbara ; Menni, Cristina ; O'Connell, Jeffrey R ; Oostra, Ben A ; Shuldiner, Alan R ; Song, Kijoung ; Vandenput, Liesbeth ; van Duijn, Cornelia M ; Vollenweider, Peter ; White, Charles C ; Boehnke, Michael ; Boettcher, Yvonne ; Cooper, Richard S ; Forouhi, Nita G ; Gieger, Christian ; Grallert, Harald ; Hingorani, Aroon ; Jørgensen, Torben ; Jousilahti, Pekka ; Kivimaki, Mika J ; Kumari, Meena ; Laakso, Markku ; Langenberg, Claudia ; Linneberg, Allan ; Luke, Amy ; Mckenzie, Colin A ; Palotie, Aarno ; Pedersen, Oluf ; Peters, Annette ; Strauch, Konstantin ; Tayo, Bamidele O ; Wareham, Nicholas J ; Bennett, David A ; Bertram, Lars ; Blangero, John ; Blüher, Matthias ; Bouchard, Claude ; Campbell, Harry ; Cho, Nam H ; Cummings, Steven R ; Czerwinski, Stefan A ; Demuth, Ilja ; Eckardt, Rahel ; Eriksson, Johan G ; Ferrucci, Luigi ; Franco, Oscar H ; Froguel, Philippe ; Gansevoort, Ron T ; Hansen, Torben ; Harris, Tamara B ; Hastie, Nicholas ; Heliövaara, Markku ; Hofman, Albert ; Jordan, Joanne M ; Jula, Antti ; Kähönen, Mika ; Kajantie, Eero ; Knekt, Paul B ; Koskinen, Seppo ; Kovacs, Peter ; Lehtimäki, Terho ; Lind, Lars ; Liu, Yongmei ; Orwoll, Eric S ; Osmond, Clive ; Perola, Markus ; Pérusse, Louis ; Raitakari, Olli T ; Rankinen, Tuomo ; Rao, Dabeeru C ; Rice, Treva K ; Rivadeneira, Fernando ; Rudan, Igor ; Salomaa, Veikko ; Sorensen, Thorkild ; Stumvoll, Michael ; Tönjes, Anke ; Towne, Bradford ; Tranah, Gregory J ; Tremblay, Angelo ; Uitterlinden, André G ; van der Harst, Pim ; Vartiainen, Erkki ; Viikari, Jorma S ; Vitart, Veronique ; Vohl, Marie-Claude ; Völzke, Henry ; Walker, Mark ; Wallaschofski, Henri ; Wild, Sarah ; Wilson, James F ; Yengo, Loïc ; Bishop, D Timothy ; Borecki, Ingrid B ; Chambers, John C ; Cupples, L Adrienne ; Dehghan, Abbas ; Deloukas, Panos ; Fatemifar, Ghazaleh ; Fox, Caroline ; Furey, Terrence S ; Franke, Lude ; Han, Jiali ; Hunter, David J ; Karjalainen, Juha ; Karpe, Fredrik ; Kaplan, Robert C ; Kooner, Jaspal S ; McCarthy, Mark I ; Murabito, Joanne M ; Morris, Andrew P ; Bishop, Julia A N ; North, Kari E ; Ohlsson, Claes ; Ong, Ken K ; Prokopenko, Inga ; Richards, J Brent ; Schadt, Eric E ; Spector, Tim D ; Widén, Elisabeth ; Willer, Cristen J ; Yang, Jian ; Ingelsson, Erik ; Mohlke, Karen L ; Hirschhorn, Joel N ; Pospisilik, John Andrew ; Zillikens, M Carola ; Lindgren, Cecilia ; Kilpeläinen, Tuomas Oskari ; Loos, Ruth J F. / New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. In: Nature Communications. 2016 ; Vol. 7.

Bibtex

@article{5ee43311ff104af7aa9c6677117b865d,
title = "New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk",
abstract = "To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF{\%}) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF{\%}) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF{\%}. Seven loci showed a larger effect on BF{\%} than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF{\%}, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF{\%} showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.",
keywords = "Biological sciences, Genetics",
author = "Yingchang Lu and Day, {Felix R} and Stefan Gustafsson and Buchkovich, {Martin L} and Jianbo Na and Veronique Bataille and Cousminer, {Diana L} and Zari Dastani and Drong, {Alexander W} and T{\~o}nu Esko and Evans, {David M} and Mario Falchi and Feitosa, {Mary F} and Teresa Ferreira and Hedman, {{\AA}sa K} and Robin Haring and Hysi, {Pirro G} and Iles, {Mark M} and Justice, {Anne E} and Stavroula Kanoni and Vasiliki Lagou and Rui Li and Xin Li and Adam Locke and Chen Lu and Reedik M{\"a}gi and Perry, {John R B} and Pers, {Tune H} and Qibin Qi and Marianna Sanna and Schmidt, {Ellen M} and Scott, {William R} and Dmitry Shungin and Alexander Teumer and Vinkhuyzen, {Anna A E} and Walker, {Ryan W} and Harm-Jan Westra and Mingfeng Zhang and Weihua Zhang and Zhao, {Jing Hua} and Zhihong Zhu and Uzma Afzal and Ahluwalia, {Tarunveer Singh} and Bakker, {Stephan J L} and Claire Bellis and Am{\'e}lie Bonnefond and Katja Borodulin and Buchman, {Aron S} and Tommy Cederholm and Choh, {Audrey C} and Choi, {Hyung Jin} and Curran, {Joanne E} and {de Groot}, {Lisette C P G M} and {De Jager}, {Philip L} and Dhonukshe-Rutten, {Rosalie A M} and Enneman, {Anke W} and Elodie Eury and Evans, {Daniel S} and Tom Forsen and Nele Friedrich and Fr{\'e}d{\'e}ric Fumeron and Garcia, {Melissa E} and Simone G{\"a}rtner and Bok-Ghee Han and Havulinna, {Aki S} and Caroline Hayward and Dena Hernandez and Hans Hillege and Till Ittermann and Kent, {Jack W} and Ivana Kolcic and Tiina Laatikainen and Jari Lahti and {Mateo Leach}, Irene and Lee, {Christine G} and Jong-Young Lee and Tian Liu and Youfang Liu and St{\'e}phane Lobbens and Marie Loh and Leo-Pekka Lyytik{\"a}inen and Carolina Medina-Gomez and Karl Micha{\"e}lsson and Nalls, {Mike A} and Nielson, {Carrie M} and Laticia Oozageer and Laura Pascoe and Lavinia Paternoster and Ozren Polašek and Samuli Ripatti and Sarzynski, {Mark A} and Shin, {Chan Soo} and Narančić, {Nina Smolej} and Dominik Spira and Priya Srikanth and Elisabeth Steinhagen-Thiessen and Sung, {Yun Ju} and Swart, {Karin M A} and Leena Taittonen and Toshiko Tanaka and Emmi Tikkanen and {van der Velde}, Nathalie and {van Schoor}, {Natasja M} and Niek Verweij and Wright, {Alan F} and Lei Yu and Zmuda, {Joseph M} and Niina Eklund and Terrence Forrester and Niels Grarup and Jackson, {Anne U} and Kati Kristiansson and Teemu Kuulasmaa and Johanna Kuusisto and Peter Lichtner and Jian'an Luan and Anubha Mahajan and Satu M{\"a}nnist{\"o} and Palmer, {Cameron D} and Ried, {Janina S} and Scott, {Robert A} and Alena Stanc{\'a}kov{\'a} and Wagner, {Peter J} and Ayse Demirkan and Angela D{\"o}ring and Vilmundur Gudnason and Kiel, {Douglas P} and Brigitte K{\"u}hnel and Massimo Mangino and Barbara Mcknight and Cristina Menni and O'Connell, {Jeffrey R} and Oostra, {Ben A} and Shuldiner, {Alan R} and Kijoung Song and Liesbeth Vandenput and {van Duijn}, {Cornelia M} and Peter Vollenweider and White, {Charles C} and Michael Boehnke and Yvonne Boettcher and Cooper, {Richard S} and Forouhi, {Nita G} and Christian Gieger and Harald Grallert and Aroon Hingorani and Torben J{\o}rgensen and Pekka Jousilahti and Kivimaki, {Mika J} and Meena Kumari and Markku Laakso and Claudia Langenberg and Allan Linneberg and Amy Luke and Mckenzie, {Colin A} and Aarno Palotie and Oluf Pedersen and Annette Peters and Konstantin Strauch and Tayo, {Bamidele O} and Wareham, {Nicholas J} and Bennett, {David A} and Lars Bertram and John Blangero and Matthias Bl{\"u}her and Claude Bouchard and Harry Campbell and Cho, {Nam H} and Cummings, {Steven R} and Czerwinski, {Stefan A} and Ilja Demuth and Rahel Eckardt and Eriksson, {Johan G} and Luigi Ferrucci and Franco, {Oscar H} and Philippe Froguel and Gansevoort, {Ron T} and Torben Hansen and Harris, {Tamara B} and Nicholas Hastie and Markku Heli{\"o}vaara and Albert Hofman and Jordan, {Joanne M} and Antti Jula and Mika K{\"a}h{\"o}nen and Eero Kajantie and Knekt, {Paul B} and Seppo Koskinen and Peter Kovacs and Terho Lehtim{\"a}ki and Lars Lind and Yongmei Liu and Orwoll, {Eric S} and Clive Osmond and Markus Perola and Louis P{\'e}russe and Raitakari, {Olli T} and Tuomo Rankinen and Rao, {Dabeeru C} and Rice, {Treva K} and Fernando Rivadeneira and Igor Rudan and Veikko Salomaa and Thorkild Sorensen and Michael Stumvoll and Anke T{\"o}njes and Bradford Towne and Tranah, {Gregory J} and Angelo Tremblay and Uitterlinden, {Andr{\'e} G} and {van der Harst}, Pim and Erkki Vartiainen and Viikari, {Jorma S} and Veronique Vitart and Marie-Claude Vohl and Henry V{\"o}lzke and Mark Walker and Henri Wallaschofski and Sarah Wild and Wilson, {James F} and Lo{\"i}c Yengo and Bishop, {D Timothy} and Borecki, {Ingrid B} and Chambers, {John C} and Cupples, {L Adrienne} and Abbas Dehghan and Panos Deloukas and Ghazaleh Fatemifar and Caroline Fox and Furey, {Terrence S} and Lude Franke and Jiali Han and Hunter, {David J} and Juha Karjalainen and Fredrik Karpe and Kaplan, {Robert C} and Kooner, {Jaspal S} and McCarthy, {Mark I} and Murabito, {Joanne M} and Morris, {Andrew P} and Bishop, {Julia A N} and North, {Kari E} and Claes Ohlsson and Ong, {Ken K} and Inga Prokopenko and Richards, {J Brent} and Schadt, {Eric E} and Spector, {Tim D} and Elisabeth Wid{\'e}n and Willer, {Cristen J} and Jian Yang and Erik Ingelsson and Mohlke, {Karen L} and Hirschhorn, {Joel N} and Pospisilik, {John Andrew} and Zillikens, {M Carola} and Cecilia Lindgren and Kilpel{\"a}inen, {Tuomas Oskari} and Loos, {Ruth J F}",
year = "2016",
month = "2",
day = "1",
doi = "10.1038/ncomms10495",
language = "English",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer Nature",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

AU - Lu, Yingchang

AU - Day, Felix R

AU - Gustafsson, Stefan

AU - Buchkovich, Martin L

AU - Na, Jianbo

AU - Bataille, Veronique

AU - Cousminer, Diana L

AU - Dastani, Zari

AU - Drong, Alexander W

AU - Esko, Tõnu

AU - Evans, David M

AU - Falchi, Mario

AU - Feitosa, Mary F

AU - Ferreira, Teresa

AU - Hedman, Åsa K

AU - Haring, Robin

AU - Hysi, Pirro G

AU - Iles, Mark M

AU - Justice, Anne E

AU - Kanoni, Stavroula

AU - Lagou, Vasiliki

AU - Li, Rui

AU - Li, Xin

AU - Locke, Adam

AU - Lu, Chen

AU - Mägi, Reedik

AU - Perry, John R B

AU - Pers, Tune H

AU - Qi, Qibin

AU - Sanna, Marianna

AU - Schmidt, Ellen M

AU - Scott, William R

AU - Shungin, Dmitry

AU - Teumer, Alexander

AU - Vinkhuyzen, Anna A E

AU - Walker, Ryan W

AU - Westra, Harm-Jan

AU - Zhang, Mingfeng

AU - Zhang, Weihua

AU - Zhao, Jing Hua

AU - Zhu, Zhihong

AU - Afzal, Uzma

AU - Ahluwalia, Tarunveer Singh

AU - Bakker, Stephan J L

AU - Bellis, Claire

AU - Bonnefond, Amélie

AU - Borodulin, Katja

AU - Buchman, Aron S

AU - Cederholm, Tommy

AU - Choh, Audrey C

AU - Choi, Hyung Jin

AU - Curran, Joanne E

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AU - Loos, Ruth J F

PY - 2016/2/1

Y1 - 2016/2/1

N2 - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

AB - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

KW - Biological sciences

KW - Genetics

U2 - 10.1038/ncomms10495

DO - 10.1038/ncomms10495

M3 - Article

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 10495

ER -