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Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)16 - 23
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume61
Early online date16 Jul 2019
DOIs
DateAccepted/In press - 13 Jun 2019
DateE-pub ahead of print (current) - 16 Jul 2019
DatePublished - 1 Dec 2019

Abstract

During development, stem cells give rise to specialised cell types in a tightly regulated, spatiotemporal manner to drive the formation of complex three-dimensional tissues. While mechanistic insights into the gene regulatory pathways that guide cell fate choices are emerging, how morphogenetic changes are coordinated with cell fate specification remains a fundamental question in organogenesis and adult tissue homeostasis. The requirement of cell contacts for Notch signalling makes it a central pathway capable of linking dynamic cellular rearrangements during tissue morphogenesis with stem cell function. Here, we highlight recent studies that support a critical role for the Notch pathway in translating microenvironmental cues into cell fate decisions, guiding the development of diverse organ systems.

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  • Full-text PDF (author’s accepted manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.ceb.2019.06.003 . Please refer to any applicable terms of use of the publisher.

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  • Fre_Fig 1

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.ceb.2019.06.003 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 5 MB, PDF document

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    Licence: CC BY-NC-ND

  • Fre_Fig 2

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.ceb.2019.06.003 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 5 MB, PDF document

    Embargo ends: 16/07/20

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    Licence: CC BY-NC-ND

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