Skip to content

Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis

Research output: Contribution to journalReview article

Standard

Notch signalling : sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis. / Lloyd-Lewis, Bethan.

In: Current Opinion in Cell Biology, Vol. 61, 01.12.2019, p. 16 - 23.

Research output: Contribution to journalReview article

Harvard

APA

Vancouver

Author

Bibtex

@article{6d225775bb0a410e92a9439e414a57ce,
title = "Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis",
abstract = "During development, stem cells give rise to specialised cell types in a tightly regulated, spatiotemporal manner to drive the formation of complex three-dimensional tissues. While mechanistic insights into the gene regulatory pathways that guide cell fate choices are emerging, how morphogenetic changes are coordinated with cell fate specification remains a fundamental question in organogenesis and adult tissue homeostasis. The requirement of cell contacts for Notch signalling makes it a central pathway capable of linking dynamic cellular rearrangements during tissue morphogenesis with stem cell function. Here, we highlight recent studies that support a critical role for the Notch pathway in translating microenvironmental cues into cell fate decisions, guiding the development of diverse organ systems.",
author = "Bethan Lloyd-Lewis",
year = "2019",
month = "7",
day = "16",
doi = "10.1016/j.ceb.2019.06.003",
language = "English",
volume = "61",
pages = "16 -- 23",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Limited",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Notch signalling

T2 - sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis

AU - Lloyd-Lewis, Bethan

PY - 2019/7/16

Y1 - 2019/7/16

N2 - During development, stem cells give rise to specialised cell types in a tightly regulated, spatiotemporal manner to drive the formation of complex three-dimensional tissues. While mechanistic insights into the gene regulatory pathways that guide cell fate choices are emerging, how morphogenetic changes are coordinated with cell fate specification remains a fundamental question in organogenesis and adult tissue homeostasis. The requirement of cell contacts for Notch signalling makes it a central pathway capable of linking dynamic cellular rearrangements during tissue morphogenesis with stem cell function. Here, we highlight recent studies that support a critical role for the Notch pathway in translating microenvironmental cues into cell fate decisions, guiding the development of diverse organ systems.

AB - During development, stem cells give rise to specialised cell types in a tightly regulated, spatiotemporal manner to drive the formation of complex three-dimensional tissues. While mechanistic insights into the gene regulatory pathways that guide cell fate choices are emerging, how morphogenetic changes are coordinated with cell fate specification remains a fundamental question in organogenesis and adult tissue homeostasis. The requirement of cell contacts for Notch signalling makes it a central pathway capable of linking dynamic cellular rearrangements during tissue morphogenesis with stem cell function. Here, we highlight recent studies that support a critical role for the Notch pathway in translating microenvironmental cues into cell fate decisions, guiding the development of diverse organ systems.

UR - http://dx.doi.org/10.1016/j.ceb.2019.06.003

U2 - 10.1016/j.ceb.2019.06.003

DO - 10.1016/j.ceb.2019.06.003

M3 - Review article

VL - 61

SP - 16

EP - 23

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

ER -