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Prospective investigation of risk factors for prostate cancer in the UK Biobank cohort study

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1562-1571
Number of pages10
JournalBritish Journal of Cancer
Volume117
Early online date14 Sep 2017
DOIs
DateAccepted/In press - 8 Aug 2017
DateE-pub ahead of print - 14 Sep 2017
DatePublished (current) - 7 Nov 2017

Abstract

Background: Prostate cancer is the most common cancer in British men but its aetiology is not well understood. We aimed to identify risk factors for prostate cancer in British males. Methods: We studied 219,335 men from the UK Biobank study who were free from cancer at baseline. Exposure data were collected at recruitment. Prostate cancer risk by the different exposures was estimated using multivariable-adjusted Cox proportional hazards models. Results: 4,575 incident cases of prostate cancer occurred during 5.6 years of follow-up. Prostate cancer risk was positively associated with: Black ethnicity (hazard ratio black vs white=2.61, 95% confidence interval=2.10-3.24), having ever had a prostate-specific antigen test (1.31, 1.23-1.40), being diagnosed with an enlarged prostate (1.54, 1.38-1.71) and having a family history of prostate cancer (1.94, 1.77-2.13). Conversely, Asian ethnicity (Asian vs white hazard ratio=0.62, 0.47-0.83), excess adiposity (body mass index [≥35 vs <25kg/m2=0.75, 0.64-0.88] and body fat [≥30.1% vs <20.5%=0.81, 0.73-0.89]), cigarette smoking (current vs never smokers=0.85, 0.77-0.95), having diabetes (0.70, 0.62-0.80), and never having had children (0.89, 0.81-0.97) or sexual intercourse (0.53, 0.33-0.84) were related to a lower risk. Conclusion: In this new large British prospective study, we identified associations with already established, putative and possible novel risk factors for being diagnosed with prostate cancer. Future research will examine associations by tumour characteristics.

    Structured keywords

  • ICEP

    Research areas

  • Risk factors, Prostate cancer, Cohort study, Prospective, UK Biobank

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Springer Nature at https://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc2017312a.html . Please refer to any applicable terms of use of the publisher.

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