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Prostate specific antigen patterns in US and European populations: comparison of six diverse cohorts

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)911-918
Number of pages8
JournalBJU International
Volume118
Issue number6
Early online date29 Jan 2016
DOIs
DateAccepted/In press - 18 Jan 2016
DateE-pub ahead of print - 29 Jan 2016
DatePublished (current) - Dec 2016

Abstract

OBJECTIVE: To determine whether there are differences in prostate specific antigen (PSA) at diagnosis or changes in PSA between US and European populations of men with and without prostate cancer.

SUBJECTS AND METHODS: Repeated measures of PSA from six clinically and geographically diverse patient cohorts: two cohorts of men with PSA-detected prostate cancer, two cohorts with clinically-detected prostate cancer and two cohorts of men without prostate cancer. Using multilevel models, average PSA at diagnosis and PSA change over time were compared between populations.

RESULTS: Annual percentage PSA change of 4-5% was similar between men without cancer and men with PSA-detected cancer. PSA at diagnosis was 1.7ng/ml lower in a US cohort of PSA-detected men (95% CI 1.3-2.0ng/ml), compared to a PSA-detected UK cohort, but there was no evidence for a different rate of PSA change between these populations.

CONCLUSION: PSA changes over time are similar in UK and US men diagnosed through PSA testing and even in men without prostate cancer. Further development of PSA models to monitor men on active surveillance should be undertaken in order to take advantage of these similarities. We found no evidence that guidelines for using PSA to monitor men cannot be passed between US and European studies. This article is protected by copyright. All rights reserved.

    Research areas

  • active surveillance, prostate specific antigen, prostate cancer

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    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at http://onlinelibrary.wiley.com/doi/10.1111/bju.13422/abstract. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 706 KB, PDF-document

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