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Reductive Coupling of Acrylates with Ketones and Ketimines by a Nickel-Catalyzed Transfer-Hydrogenative Strategy

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)13824-13828
Number of pages5
JournalAngewandte Chemie International Edition
Volume56
Journal issue44
Early online date4 Sep 2017
DOIs
StatePublished - 23 Oct 2017

Abstract

Nickel-catalyzed coupling of benzyl acrylates with activated ketones and imines provides γ-butyrolactones and lactams, respectively. The benzyl alcohol byproduct released during the lactonization/lactamization event is relayed to the next cycle where it serves as the reductant for C−C bond formation. This strategy represents a conceptually unique approach to transfer-hydrogenative C−C bond formation, thus providing examples of reductive heterocyclizations where hydrogen embedded within an alcohol leaving group facilitates turnover.

    Research areas

  • alcohols, lactones, nickel, spiro compounds, transfer hydrogenation

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Wiley at http://onlinelibrary.wiley.com/doi/10.1002/anie.201707139/abstract . Please refer to any applicable terms of use of the publisher.

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    License: CC BY

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