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Sex-specific differences in cardiovascular and metabolic hormones with integrated signalling in the paraventricular nucleus of the hypothalamus

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1373-1379
Number of pages7
JournalExperimental Physiology
Volume102
Issue number11
Early online date24 Aug 2017
DOIs
DateAccepted/In press - 20 Jul 2017
DateE-pub ahead of print - 24 Aug 2017
DatePublished (current) - 1 Nov 2017

Abstract

Many traditional cardiovascular hormones have been implicated in metabolic function. Conversely, many hormones traditionally involved in metabolic regulation have an effect on cardiovascular function. Many of these signalling molecules exert such effects through specific actions in the paraventricular nucleus, an integrative autonomic control centre located in the hypothalamus. Here, we focus on four cardiovascular/metabolic peptide hormones that signal within the paraventricular nucleus, namely angiotensin II, orexin, adiponectin and nesfatin‐1. Each of these hormones has specific electrophysiological effects on paraventricular nucleus neurons that can be related to its physiological actions. In addition, we introduce preliminary transcriptomic data indicating that the genes for some of these hormones and their receptors have sex‐specific differential expression.

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