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Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients: Potential Implication of the CD200/CD200R Axis in the Disease Course

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Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients : Potential Implication of the CD200/CD200R Axis in the Disease Course. / Sakthivel, Priya; Breithaupt, Angele; Gereke, Marcus; Copland, David A; Schulz, Christian; Gruber, Achim D; Dick, Andrew D; Schreiber, Jens; Bruder, Dunja.

In: Lung, Vol. 195, No. 1, 02.2017, p. 59–68.

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Sakthivel, Priya ; Breithaupt, Angele ; Gereke, Marcus ; Copland, David A ; Schulz, Christian ; Gruber, Achim D ; Dick, Andrew D ; Schreiber, Jens ; Bruder, Dunja. / Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients : Potential Implication of the CD200/CD200R Axis in the Disease Course. In: Lung. 2017 ; Vol. 195, No. 1. pp. 59–68.

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@article{24270005e5ea452585919f6937fdf41d,
title = "Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients: Potential Implication of the CD200/CD200R Axis in the Disease Course",
abstract = "BACKGROUND: COPD represents a multifactorial lung disorder with high morbidity and mortality. Despite intensive research concerning the underlying disease mechanisms, the involvement of the CD200/CD200R axis in supporting or preventing the onset of COPD has not yet been addressed. Since the CD200/CD200R axis is crucially implicated in the maintenance of pulmonary immune homeostasis, we hypothesized that it might be involved in controlling the onset of COPD.METHODS: To address this, we analyzed the serum samples from COPD patients and normal controls for soluble (s) CD200 and correlated the data to COPD-relevant clinical parameters. In addition, basic studies were conducted in CD200-deficient and wild-type mice in which COPD-like inflammation was induced with elastase/LPS followed by lung and serum component analysis.RESULTS: We observed a positive correlation between serum sCD200 and IL-6 levels as well as a trend toward a negative correlation of sCD200 with vitamin D3 in COPD patients. Further investigations in mice revealed that despite elevated serum concentration of MMP-9 in CD200KO mice, the early onset of COPD-like lung inflammation was similar in CD200-deficient and wild-type animals in terms of immune cell infiltration, emphysematous changes, and mucus overproduction.CONCLUSIONS: While our murine studies suggest that the co-inhibitory molecule CD200 does not appear to play a prominent role in the early onset of COPD-like features, correlation of sCD200 serum levels with COPD-related parameters in humans with established disease revealed that the CD200/CD200R axis may be mechanistically linked to the disease course in COPD patients.",
keywords = "CD200/CD200R axis, COPD, LPS/elastase model, CD200-deficient mice, MMP-9",
author = "Priya Sakthivel and Angele Breithaupt and Marcus Gereke and Copland, {David A} and Christian Schulz and Gruber, {Achim D} and Dick, {Andrew D} and Jens Schreiber and Dunja Bruder",
year = "2017",
month = "2",
doi = "10.1007/s00408-016-9962-4",
language = "English",
volume = "195",
pages = "59–68",
journal = "Lung",
issn = "0341-2040",
publisher = "Springer US",
number = "1",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients

T2 - Potential Implication of the CD200/CD200R Axis in the Disease Course

AU - Sakthivel, Priya

AU - Breithaupt, Angele

AU - Gereke, Marcus

AU - Copland, David A

AU - Schulz, Christian

AU - Gruber, Achim D

AU - Dick, Andrew D

AU - Schreiber, Jens

AU - Bruder, Dunja

PY - 2017/2

Y1 - 2017/2

N2 - BACKGROUND: COPD represents a multifactorial lung disorder with high morbidity and mortality. Despite intensive research concerning the underlying disease mechanisms, the involvement of the CD200/CD200R axis in supporting or preventing the onset of COPD has not yet been addressed. Since the CD200/CD200R axis is crucially implicated in the maintenance of pulmonary immune homeostasis, we hypothesized that it might be involved in controlling the onset of COPD.METHODS: To address this, we analyzed the serum samples from COPD patients and normal controls for soluble (s) CD200 and correlated the data to COPD-relevant clinical parameters. In addition, basic studies were conducted in CD200-deficient and wild-type mice in which COPD-like inflammation was induced with elastase/LPS followed by lung and serum component analysis.RESULTS: We observed a positive correlation between serum sCD200 and IL-6 levels as well as a trend toward a negative correlation of sCD200 with vitamin D3 in COPD patients. Further investigations in mice revealed that despite elevated serum concentration of MMP-9 in CD200KO mice, the early onset of COPD-like lung inflammation was similar in CD200-deficient and wild-type animals in terms of immune cell infiltration, emphysematous changes, and mucus overproduction.CONCLUSIONS: While our murine studies suggest that the co-inhibitory molecule CD200 does not appear to play a prominent role in the early onset of COPD-like features, correlation of sCD200 serum levels with COPD-related parameters in humans with established disease revealed that the CD200/CD200R axis may be mechanistically linked to the disease course in COPD patients.

AB - BACKGROUND: COPD represents a multifactorial lung disorder with high morbidity and mortality. Despite intensive research concerning the underlying disease mechanisms, the involvement of the CD200/CD200R axis in supporting or preventing the onset of COPD has not yet been addressed. Since the CD200/CD200R axis is crucially implicated in the maintenance of pulmonary immune homeostasis, we hypothesized that it might be involved in controlling the onset of COPD.METHODS: To address this, we analyzed the serum samples from COPD patients and normal controls for soluble (s) CD200 and correlated the data to COPD-relevant clinical parameters. In addition, basic studies were conducted in CD200-deficient and wild-type mice in which COPD-like inflammation was induced with elastase/LPS followed by lung and serum component analysis.RESULTS: We observed a positive correlation between serum sCD200 and IL-6 levels as well as a trend toward a negative correlation of sCD200 with vitamin D3 in COPD patients. Further investigations in mice revealed that despite elevated serum concentration of MMP-9 in CD200KO mice, the early onset of COPD-like lung inflammation was similar in CD200-deficient and wild-type animals in terms of immune cell infiltration, emphysematous changes, and mucus overproduction.CONCLUSIONS: While our murine studies suggest that the co-inhibitory molecule CD200 does not appear to play a prominent role in the early onset of COPD-like features, correlation of sCD200 serum levels with COPD-related parameters in humans with established disease revealed that the CD200/CD200R axis may be mechanistically linked to the disease course in COPD patients.

KW - CD200/CD200R axis

KW - COPD

KW - LPS/elastase model

KW - CD200-deficient mice

KW - MMP-9

U2 - 10.1007/s00408-016-9962-4

DO - 10.1007/s00408-016-9962-4

M3 - Article

VL - 195

SP - 59

EP - 68

JO - Lung

JF - Lung

SN - 0341-2040

IS - 1

ER -