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Supported lipid bilayers with encapsulated quantum dots (QDs) via liposome fusion: Effect of QD size on bilayer formation and structure

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Supported lipid bilayers with encapsulated quantum dots (QDs) via liposome fusion: Effect of QD size on bilayer formation and structure. / Wlodek, Magdalena; Kolasińska-Sojka, Marta; Szuwarzyński, Michał; Kereïche, Sami; Kováčik, Lubomir; Zhou, Liangzhi; Islas Flores, Luisa E; Warszyński, Piotr; Briscoe, Wuge H.

In: Nanoscale, Vol. 10, No. 37, 07.10.2018, p. 17965-17974.

Research output: Contribution to journalArticle

Harvard

Wlodek, M, Kolasińska-Sojka, M, Szuwarzyński, M, Kereïche, S, Kováčik, L, Zhou, L, Islas Flores, LE, Warszyński, P & Briscoe, WH 2018, 'Supported lipid bilayers with encapsulated quantum dots (QDs) via liposome fusion: Effect of QD size on bilayer formation and structure', Nanoscale, vol. 10, no. 37, pp. 17965-17974. https://doi.org/10.1039/C8NR05877F

APA

Wlodek, M., Kolasińska-Sojka, M., Szuwarzyński, M., Kereïche, S., Kováčik, L., Zhou, L., ... Briscoe, W. H. (2018). Supported lipid bilayers with encapsulated quantum dots (QDs) via liposome fusion: Effect of QD size on bilayer formation and structure. Nanoscale, 10(37), 17965-17974. https://doi.org/10.1039/C8NR05877F

Vancouver

Wlodek M, Kolasińska-Sojka M, Szuwarzyński M, Kereïche S, Kováčik L, Zhou L et al. Supported lipid bilayers with encapsulated quantum dots (QDs) via liposome fusion: Effect of QD size on bilayer formation and structure. Nanoscale. 2018 Oct 7;10(37):17965-17974. https://doi.org/10.1039/C8NR05877F

Author

Wlodek, Magdalena ; Kolasińska-Sojka, Marta ; Szuwarzyński, Michał ; Kereïche, Sami ; Kováčik, Lubomir ; Zhou, Liangzhi ; Islas Flores, Luisa E ; Warszyński, Piotr ; Briscoe, Wuge H. / Supported lipid bilayers with encapsulated quantum dots (QDs) via liposome fusion: Effect of QD size on bilayer formation and structure. In: Nanoscale. 2018 ; Vol. 10, No. 37. pp. 17965-17974.

Bibtex

@article{c9d1cd96931b41129f5548e03d7d3c90,
title = "Supported lipid bilayers with encapsulated quantum dots (QDs) via liposome fusion: Effect of QD size on bilayer formation and structure",
abstract = "Understanding interactions between functional nanoparticles and lipid bilayers is important to many emerging biomedical and bioanalytical applications. In this paper, we report incorporation of hydrophobic cadmium sulphide quantum dots (CdS QDs) into mixed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) / 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE) liposomes, and into their supported bilayers (SLBs). The QDs were found embedded in the hydrophobic regions of the liposomes and the supported bilayers, which retained the QD fluorescent properties. In particular, we studied the effect of the QD size (2.7–5.4 nm in diameter) on the formation kinetics and structure of the supported POPC/POPE bilayers, monitored in situ using quartz crystal microbalance with dissipation monitoring (QCM-D), as the liposomes ruptured onto the substrate. The morphology of the obtained QD-lipid hybrid bilayers was studied using atomic force microscopy (AFM), and their structure by synchrotron X-ray reflectivity (XRR). It was shown that the incorporation of hydrophobic QDs promoted bilayer formation on the PEI cushion, evident from the rupture and fusion of the QD-endowed liposomes at a lower surface coverage compared to the liposomes without QDs. Furthermore, the degree of disruption in the supported bilayer structure caused by the QDs was found to be correlated with the QD size. Our results provide mechanistic insights into the kinetics of the rupturing and formation process of QD-endowed supported lipid bilayers via liposome fusion on polymer cushions.",
author = "Magdalena Wlodek and Marta Kolasińska-Sojka and Michał Szuwarzyński and Sami Kere{\"i}che and Lubomir Kov{\'a}čik and Liangzhi Zhou and {Islas Flores}, {Luisa E} and Piotr Warszyński and Briscoe, {Wuge H}",
year = "2018",
month = "10",
day = "7",
doi = "10.1039/C8NR05877F",
language = "English",
volume = "10",
pages = "17965--17974",
journal = "Nanoscale",
issn = "2040-3364",
publisher = "Royal Society of Chemistry",
number = "37",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Supported lipid bilayers with encapsulated quantum dots (QDs) via liposome fusion: Effect of QD size on bilayer formation and structure

AU - Wlodek, Magdalena

AU - Kolasińska-Sojka, Marta

AU - Szuwarzyński, Michał

AU - Kereïche, Sami

AU - Kováčik, Lubomir

AU - Zhou, Liangzhi

AU - Islas Flores, Luisa E

AU - Warszyński, Piotr

AU - Briscoe, Wuge H

PY - 2018/10/7

Y1 - 2018/10/7

N2 - Understanding interactions between functional nanoparticles and lipid bilayers is important to many emerging biomedical and bioanalytical applications. In this paper, we report incorporation of hydrophobic cadmium sulphide quantum dots (CdS QDs) into mixed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) / 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE) liposomes, and into their supported bilayers (SLBs). The QDs were found embedded in the hydrophobic regions of the liposomes and the supported bilayers, which retained the QD fluorescent properties. In particular, we studied the effect of the QD size (2.7–5.4 nm in diameter) on the formation kinetics and structure of the supported POPC/POPE bilayers, monitored in situ using quartz crystal microbalance with dissipation monitoring (QCM-D), as the liposomes ruptured onto the substrate. The morphology of the obtained QD-lipid hybrid bilayers was studied using atomic force microscopy (AFM), and their structure by synchrotron X-ray reflectivity (XRR). It was shown that the incorporation of hydrophobic QDs promoted bilayer formation on the PEI cushion, evident from the rupture and fusion of the QD-endowed liposomes at a lower surface coverage compared to the liposomes without QDs. Furthermore, the degree of disruption in the supported bilayer structure caused by the QDs was found to be correlated with the QD size. Our results provide mechanistic insights into the kinetics of the rupturing and formation process of QD-endowed supported lipid bilayers via liposome fusion on polymer cushions.

AB - Understanding interactions between functional nanoparticles and lipid bilayers is important to many emerging biomedical and bioanalytical applications. In this paper, we report incorporation of hydrophobic cadmium sulphide quantum dots (CdS QDs) into mixed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) / 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE) liposomes, and into their supported bilayers (SLBs). The QDs were found embedded in the hydrophobic regions of the liposomes and the supported bilayers, which retained the QD fluorescent properties. In particular, we studied the effect of the QD size (2.7–5.4 nm in diameter) on the formation kinetics and structure of the supported POPC/POPE bilayers, monitored in situ using quartz crystal microbalance with dissipation monitoring (QCM-D), as the liposomes ruptured onto the substrate. The morphology of the obtained QD-lipid hybrid bilayers was studied using atomic force microscopy (AFM), and their structure by synchrotron X-ray reflectivity (XRR). It was shown that the incorporation of hydrophobic QDs promoted bilayer formation on the PEI cushion, evident from the rupture and fusion of the QD-endowed liposomes at a lower surface coverage compared to the liposomes without QDs. Furthermore, the degree of disruption in the supported bilayer structure caused by the QDs was found to be correlated with the QD size. Our results provide mechanistic insights into the kinetics of the rupturing and formation process of QD-endowed supported lipid bilayers via liposome fusion on polymer cushions.

U2 - 10.1039/C8NR05877F

DO - 10.1039/C8NR05877F

M3 - Article

VL - 10

SP - 17965

EP - 17974

JO - Nanoscale

JF - Nanoscale

SN - 2040-3364

IS - 37

ER -