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Temporal control of glucocorticoid neurodynamics and its relevance for brain homeostasis, neuropathology and glucocorticoid-based therapeutics

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)12-25
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
Volume61
Early online date3 Dec 2015
DOIs
DateAccepted/In press - 19 Nov 2015
DateE-pub ahead of print - 3 Dec 2015
DatePublished (current) - Feb 2016

Abstract

Glucocorticoids mediate plethora of actions throughout the human body. Within the brain, they modulate aspects of immune system and neuroinflammatory processes, interfere with cellular metabolism and viability, interact with systems of neurotransmission and regulate neural rhythms. The influence of glucocorticoids on memory and emotional behaviour is well known and there is increasing evidence for their involvement in many neuropsychiatric pathologies. These effects, which at times can be in opposing directions, depend not only on the concentration of glucocorticoids but also the duration of their presence, the temporal relationship between their fluctuations, the co-influence of other stimuli, and the overall state of brain activity. Moreover, they are region- and cell type-specific. The molecular basis of such diversity of effects lies on the orchestration of the spatiotemporal interplay between glucocorticoid- and mineralocorticoid receptors, and is achieved through complex dynamics, mainly mediated via the circadian and ultradian pattern of glucocorticoid secretion. More sophisticated methodologies are therefore required to better approach the study of these hormones and improve the effectiveness of glucocorticoid-based therapeutics.

    Research areas

  • Glucocorticoid pulsatility, Ultradian rhythmicity, Glucocorticoid-based therapeutics; Neuropsychopathology, Glucocorticoid neurodynamics, Mineralocorticoid receptors, Glucocorticoid receptors

    Structured keywords

  • CRICBristol

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    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at http://www.sciencedirect.com/science/article/pii/S0149763415300129. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 1016 KB, PDF-document

    Licence: CC BY-NC-ND

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