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The effect of surgical versus transcatheter aortic valve replacement on endothelial function. An observational study

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalInternational Journal of Surgery
Volume63
Early online date28 Jan 2019
DOIs
DateAccepted/In press - 19 Jan 2019
DateE-pub ahead of print - 28 Jan 2019
DatePublished (current) - 1 Mar 2019

Abstract

Background The effects of surgical aortic valve replacement versus transcatheter aortic valve replacement on endothelial function are unknown. We investigated the effects of surgical and transcatheter aortic valve replacement on early and 90-day endothelial function measured by brachial flow mediated dilation and apoptotic rate in the human umbilical vein endothelial cells in patients with significant aortic stenosis, intermediate risk of surgery, and no coronary artery disease. Methods We conducted a prospective observational case control single-blind study at a single tertiary center. Endothelial function was measured at baseline, early post-procedure (4 days), and follow-up (90 days). A blood pressure cuff was used to elicit reactive hyperemia for measuring brachial wall shear stress and flow mediated dilation. The apoptosis rate was observed in the human umbilical vein endothelial cells after 48-h incubation with 20% serum from patients. The rate of apoptosis was assessed by determining the number of annexin V and propidium iodide positive cells by flow cytometry. Results Early post-procedure flow dilation was significant lower in the surgical group (p < 0.003). At follow-up, both groups showed incremental increases in flow mediated dilation. Surgical group apoptotic rate did not significantly change, while transcatheter apoptotic rate steadily decreased, suggesting a trend toward improved endothelial function. Conclusions The data suggest that conventional surgical aortic valve replacement may be associated with an early and transient decrease in endothelial function, likely due to the use of cardio-pulmonary bypass.

    Structured keywords

  • Centre for Surgical Research

    Research areas

  • Aortic valve, Endothelial function, flow-mediated dilation, Aortic valve replacement, transcatheter aortic valve replacement

Documents

Documents

  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://www.sciencedirect.com/science/article/pii/S1743919119300214. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 181 KB, PDF document

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  • Supplementary Table 1 PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://www.sciencedirect.com/science/article/pii/S1743919119300214. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 39 KB, PDF document

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    Licence: CC BY-NC-ND

  • Supplementary Table 2 PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://www.sciencedirect.com/science/article/pii/S1743919119300214. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 100 KB, PDF document

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    Licence: CC BY-NC-ND

  • Supplementary Figure 1 PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://www.sciencedirect.com/science/article/pii/S1743919119300214. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 59 KB, PDF document

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    Licence: CC BY-NC-ND

  • Supplementary Figure 2 PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://www.sciencedirect.com/science/article/pii/S1743919119300214. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 61 KB, PDF document

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    Licence: CC BY-NC-ND

  • Supplementary Figure 3 PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://www.sciencedirect.com/science/article/pii/S1743919119300214. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 77 KB, PDF document

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    Licence: CC BY-NC-ND

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