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The transcription factor MEF2A plays a key role in the differentiation/maturation of rat neural stem cells into neurons

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)645-649
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume500
Issue number3
Early online date23 Apr 2018
DOIs
DateAccepted/In press - 16 Apr 2018
DateE-pub ahead of print - 23 Apr 2018
DatePublished (current) - 7 Jun 2018

Abstract

Neural stem cells (NSCs) are self-renewing multipotent stem cells that can be proliferated in vitro and differentiated into neuronal and/or glial lineages, making them an ideal model to study the processes involved in neuronal differentiation. Here we have used NSCs to investigate the role of the transcription factor MEF2A in neuronal differentiation and development in vitro. We show that although MEF2A is present in undifferentiated NSCs, following differentiation it is expressed at significantly higher levels in a subset of neuronal compared to non-neuronal cells. Furthermore, shRNA-mediated knockdown of MEF2A reduces the number of NSC-derived neurons compared to non-neuronal cells after differentiation. Together, these data indicate that MEF2A participates in neuronal differentiation/maturation from NSCs.

    Research areas

  • Development, Differentiation, MEF2, Neural stem cells, Neurons, Transcription factor

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Elsevier at https://www.sciencedirect.com/science/article/pii/S0006291X18309045?via%3Dihub . Please refer to any applicable terms of use of the publisher.

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