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Using Y-Chromosomal Haplogroups in Genetic Association Studies and Suggested Implications

Research output: Contribution to journalArticle

Original languageEnglish
Article number45
Number of pages11
JournalGenes
Volume9
Issue number1
Early online date22 Jan 2018
DOIs
DateSubmitted - 1 Apr 2016
DateAccepted/In press - 16 Jan 2018
DateE-pub ahead of print - 22 Jan 2018
DatePublished (current) - Jan 2018

Abstract

Y-chromosomal (Y-DNA) haplogroups are more widely used in population genetics than in genetic epidemiology, although associations between Y-DNA haplogroups and several traits, including cardiometabolic traits, have been reported. In apparently homogeneous populations defined by principal component analyses, there is still Y-DNA haplogroup variation which will result from population history. Therefore, hidden stratification and/or differential phenotypic effects by Y-DNA haplogroups could exist. To test this, we hypothesised that stratifying individuals according to their Y-DNA haplogroups before testing for associations between autosomal single nucleotide polymorphisms (SNPs) and phenotypes will yield difference in association. For proof of concept, we derived Y-DNA haplogroups from 6537 males from two epidemiological cohorts, Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 5080; 816 Y-DNA SNPs) and the 1958 Birth Cohort (n = 1457; 1849 Y-DNA SNPs), and studied the robust associations between 32 SNPs and body mass index (BMI), including SNPs in or near Fat Mass and Obesity-associated protein (FTO) which yield the strongest effects. Overall, no association was replicated in both cohorts when Y-DNA haplogroups were considered and this suggests that, for BMI at least, there is little evidence of differences in phenotype or SNP association by Y-DNA structure. Further studies using other traits, phenome-wide association studies (PheWAS), other haplogroups and/or autosomal SNPs are required to test the generalisability and utility of this approach.

Additional information

Special Issue: Complex Genetic Loci

    Research areas

  • 1958 Birth Cohort, Avon longitudinal study of parents and children, Body mass index, Haplogroups, Y-DNA

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via MDPI at http://www.mdpi.com/2073-4425/9/1/45 . Please refer to any applicable terms of use of the publisher.

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