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WT1 the oncogene: a tale of death and HtrA

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)153-5
Number of pages3
JournalMolecular Cell
Volume37
Issue number2
DOIs
DatePublished - 29 Jan 2010

Abstract

Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.

    Research areas

  • Antineoplastic Agents, Apoptosis, Genes, Wilms Tumor, Humans, Mitochondrial Proteins, Neoplasms, Serine Endopeptidases, Stress, Physiological, WT1 Proteins, Comment, Journal Article

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